{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T18:05:43Z","timestamp":1699121143907},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1970,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>[1,2-<jats:sup>3<\/jats:sup>H] and [7\u03b1-<jats:sup>3<\/jats:sup>H] testosterone* and [4-<jats:sup>14<\/jats:sup>C] androstenedione incubated with hydatidiform mole tissue are converted into oestrone and oestradiol. No conversion into oestriol was observed. The radiometabolites were purified using TLC in different systems and crystallization to a constant specific activity and\/or <jats:sup>14<\/jats:sup>C\/<jats:sup>3<\/jats:sup>H ratio.<\/jats:p>\n        <jats:p>Appropriate corrections were made for endogenous production of steroids during the incubation.<\/jats:p>\n        <jats:p>From time-experiments with [4-<jats:sup>14<\/jats:sup>C] androstenedione and [7\u03b1-<jats:sup>3<\/jats:sup>H] or [1,2-<jats:sup>3<\/jats:sup>H] testosterone it appears, that androstenedione is a more effective precursor than testosterone for oestrone and oestradiol.<\/jats:p>\n        <jats:p>Equilibrium oestrone \u21cb oestradiol is established more rapidly than androstenedione \u21cb testosterone. Conversion of androstenedione into oestrone is more effective than conversion of testosterone into androstenedione. Data are reported in agreement with the hypothesis of a direct pathway from testosterone to oestradiol in the shorter periods of incubation.<\/jats:p>\n        <jats:p>Determination of the endogenous pools of oestrone, oestradiol, testosterone and androstenedione synthesized during the incubations indicates that oestrone is the most important steroid produced <jats:italic>in vitro<\/jats:italic>.<\/jats:p>","DOI":"10.1530\/acta.0.0640017","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:59:13Z","timestamp":1229374753000},"page":"17-37","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":5,"title":["CONVERSION OF ANDROGENS INTO OESTROGENS BY HYDATIDIFORM MOLES IN VITRO"],"prefix":"10.1093","volume":"64","author":[{"given":"Hans L.","family":"Houtzager","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubertus A.","family":"van Leusden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Siemerink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/64\/1\/acta_64_1_002.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/64\/1\/acta_64_1_002.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:10:56Z","timestamp":1676391056000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/64\/1\/17\/6893869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0640017","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,5]]}}}