{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:55:15Z","timestamp":1771005315797,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1971,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Vascular volume was expanded in 10 normal, non-hydrated women with an infusion of 1000 ml of an iso-oncotic solution over 1.5 to 2 h and the effect of such treatment on uterine activity was studied on day 2-4 of the menstrual cycle. Three different plasma expanders were used and the results were similar with them all. The uterine recordings taken by means of a small intra-uterine balloon showed no immediate effect of the infusions, but about two hours later a marked suppression in uterine activity was noted in all and in seven instances the contractions disappeared almost completely and remained absent for two to three hours at least. Vasopressin elicited strong uterine contractions when the activity had been suppressed by plasma expansion. In a control group of 10 menstruating women who received no infusion, a decrease in uterine activity was never observed; on the contrary, the activity increased in 8 of the 10 subjects. In a group of ten receiving isotonic saline, uterine activity either remained unchanged or was somewhat reduced but much less than after infusion of iso-oncotic solutions. During the day a gradual decrease in the hourly diuresis occurred in the control group, whereas in the experimental group the urine output started to increase one to two hours following the infusion. The women receiving a saline infusion showed a slight transient increase in diuresis. It is suggested that the suppression of uterine activity following infusion of iso-oncotic solutions is due to reduction in vasopressin secretion brought about by the increase in vascular volume, and that endogenous vasopressin is a physiological stimulus for the uterine contractions during menstruation.<\/jats:p>","DOI":"10.1530\/acta.0.0660183","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:19:36Z","timestamp":1229375976000},"page":"183-192","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":3,"title":["SUPPRESSION OF UTERINE ACTIVITY DURING MENSTRUATION BY EXPANSION OF THE PLASMA VOLUME"],"prefix":"10.1093","volume":"66","author":[{"given":"Anna-Riitta","family":"Fuchs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsimar M.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/66\/1\/acta_66_1_018.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/66\/1\/acta_66_1_018.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:12:09Z","timestamp":1676391129000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/66\/1\/183\/6836941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0660183","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,1]]}}}