{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:00:54Z","timestamp":1758819654633},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1971,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Conscious trained sheep with adrenal autotransplants were allowed to become severely Na<jats:sup>+<\/jats:sup> deficient by uncompensated salivary loss via a unilateral permanent parotid fistula. Hypertonic NaHCO<jats:sub>3<\/jats:sub> was infused into the adrenal artery at concentrations and rates appropriate to locally change adrenal plasma (Na<jats:sup>+<\/jats:sup>), (K<jats:sup>+<\/jats:sup>) and (HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup>) to Na<jats:sup>+<\/jats:sup> replete levels without significant alteration of body Na<jats:sup>+<\/jats:sup> status, or systemic ionic concentrations. After 2 hours of infusion aldosterone secretion rate was not significantly decreased; after 4\u20136 hours of infusion aldosterone secretion rate was significantly reduced but remained at levels appropriate for moderate to severe Na<jats:sup>+<\/jats:sup> deficiency. The direct adrenal action of plasma ionic changes then, fails to explain the fall in secretion rate to close to Na replete levels which is seen over 2\u20136 hours after an animal rapidly corrects body Na<jats:sup>+<\/jats:sup> deficit by drinking 2\u20133 1 of hypertonic NaHCO<jats:sub>3<\/jats:sub> solution (300 mEq.\/l) \u2013 since the adrenal arterial infusion produced the same ionic changes as occur systemically after drinking adequate NaHCO<jats:sub>3<\/jats:sub> to correct body Na<jats:sup>+<\/jats:sup> deficit.<\/jats:p>","DOI":"10.1530\/acta.0.0660448","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:19:36Z","timestamp":1229375976000},"page":"448-461","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":7,"title":["THE EFFECT OF ADRENAL ARTERIAL INFUSION OF HYPERTONIC NaHCO3 SOLUTION ON ALDOSTERONE SECRETION IN SODIUM DEFICIENT SHEEP"],"prefix":"10.1093","volume":"66","author":[{"given":"J. R.","family":"Blair-West","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"Coghlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Denton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Funder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. A.","family":"Scoggins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. D.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/66\/3\/acta_66_3_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/66\/3\/acta_66_3_005.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:12:19Z","timestamp":1676391139000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/66\/3\/448\/6836929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0660448","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,3]]}}}