{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:24:06Z","timestamp":1676438646342},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1971,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>It is generally assumed that urinary excretion of testosterone glucuronide (TG) represents a relatively constant fraction (about 1 %) of the circulating testosterone which is metabolized. For this urinary TG to be a reliable indicator of testosterone production, the constancy of the fractional conversion of endogenous testosterone to urinary TG must be validated. Small changes in a low fractional conversion would induce large errors in the estimate of endogenous production. Following intravenous injection of [4-<jats:sup>14<\/jats:sup>C] testosterone, the per cent of the injected material found in the testosterone glucuronide fraction of a 48 hour urine collection was determined in several groups of subjects. In eight males the value ranged from 0.80 to 2.34%; in ten normal females from 0.26 to 0.84%; and in fifteen hirsute females from 0.05 to 0.80 %, a 16-fold difference. It is concluded that the assessment of endogenous testosterone production from urinary TG is materially influenced by changes in fractional conversion, and this introduces a very large degree of unreliability in the interpretation of urinary TG excretion data.<\/jats:p>","DOI":"10.1530\/acta.0.0670371","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:19:36Z","timestamp":1229375976000},"page":"371-383","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":3,"title":["URINARY TESTOSTERONE GLUCURONIDE AS A MEASURE OF ENDOGENOUS TESTOSTERONE PRODUCTION"],"prefix":"10.1093","volume":"67","author":[{"given":"Joseph W.","family":"Goldzieher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary C.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/67\/2\/acta_67_2_017.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/67\/2\/acta_67_2_017.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:13:30Z","timestamp":1676391210000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/67\/2\/371\/6840772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,6]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0670371","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,6]]}}}