{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:24:20Z","timestamp":1676438660627},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>A newborn anencephalic monster was injected with carbon-14 labelled dehydro<jats:italic>epi<\/jats:italic>androsterone and tritium labelled androstenedione and metabolites recovered from various tissues and blood specimens were analysed. Dehydroepiandrosterone was readily converted to dehydro<jats:italic>epi<\/jats:italic>androsterone sulphate in all tissues studied. Furthermore, unconjugated as well as conjugated 5-androstene-3\u03b2,17\u03b2-diol and conjugated 16\u03b1-hydroxy-dehydro<jats:italic>epi<\/jats:italic>androsterone were isolated from the liver. Very little, if any, of the injected dehydro<jats:italic>epi<\/jats:italic>androsterone was converted to \u0394<jats:sup>4<\/jats:sup>-3-ketosteroids, ring A reduction products or oestrogens.<\/jats:p>\n        <jats:p>On the other hand, androstenedione was rapidly metabolized to testosterone, a variety of unconjugated and conjugated reduction products and conjugated oestrogens.<\/jats:p>\n        <jats:p>From the different tissues, the following unconjugated compounds were isolated in a radiochemically homogenous form: testosterone (liver, blood, kidneys, gastrointestinal tract, lungs, thymus), 5\u03b2-androstanedione (liver), 5\u03b2-androsterone (liver, blood, kidneys, gastrointestinal tract, lungs, thymus), <jats:italic>epi<\/jats:italic>-5\u03b2-androsterone (liver), 5\u03b2-androstane-3\u03b1,17\u03b2-diol and 5\u03b1-androstanedione (blood, combined extract of all organs), 5\u03b1-androsterone (liver, blood, kidneys, gastrointestinal tract, lungs, thymus), 5\u03b1-dihydrotestosterone (combined foetal organs except the liver) and <jats:italic>epi<\/jats:italic>-5\u03b1-androsterone (blood and combined foetal organs except the liver). From the solvolysed <jats:italic>conjugated<\/jats:italic> fraction, the following steroids were isolated: 5\u03b2-androstane-3\u03b1,17\u03b2-diol (liver), 5\u03b2-androsterone (liver, blood, kidneys, gastrointestinal tract, lungs, thymus), <jats:italic>epi<\/jats:italic>-5\u03b2-androsterone (liver), 5\u03b1-androsterone (liver, blood, kidneys, gastrointestinal tract, lungs, thymus), testosterone (liver, blood, kidneys, gastrointestinal tract, lungs, thymus). The 5\u03b2-forms were predominant in the liver, whereas the 5\u03b1-forms dominated the pattern in all other tissues studied, including the blood.<\/jats:p>\n        <jats:p>The data indicate that the androgen metabolism of the anencephalic monster studied, did not differ qualitatively from that of midterm foetuses.<\/jats:p>","DOI":"10.1530\/acta.0.0710600","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:19:36Z","timestamp":1229375976000},"page":"600-613","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["METABOLISM OF DEHYDROEPIANDROSTERONE AND ANDROSTENEDIONE IN A NEWBORN ANENCEPHALIC MONSTER AT TERM"],"prefix":"10.1093","volume":"71","author":[{"given":"G.","family":"Benagiano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. de la","family":"Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gualtieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Diczfalusy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/71\/3\/acta_71_3_017.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/71\/3\/acta_71_3_017.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:18:22Z","timestamp":1676391502000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/71\/3\/600\/6841582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,11]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0710600","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,11]]}}}