{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:35:34Z","timestamp":1756996534554},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>The source of the large amounts of circulating progesterone and the smaller quantities of 17\u03b1-hydroxyprogesterone in Hydatidiform Mole was studied by measuring progesterone, 17\u03b1-hydroxyprogesterone and 20\u03b1-hydroxyprogesterone in petroleum ether extracts of mole vesicle fluid and theca lutein cyst fluid following chromatography. The progesterone concentration in 10 samples of mole vesicle fluid ranged from 261\u20131493 ng\/ml (mean 724 ng\/ml) and was 8.6 times higher than the concentration in the serum. The chromatogram of the theca lutein cyst fluid showed a large peak of progesterone followed by two large secondary peaks of 20\u03b1-hydroxyprogesterone and 17\u03b1-hydroxyprogesterone. In 3 patients with benign Hydatidiform Mole, progesterone and human chorionic gonadotrophin rapidly decreased during the first 48 hours following evacuation of the mole. Thereafter, progesterone disappeared from the serum before HCG in one case, together with HCG in the second, and remained at low concentrations for 3 months in the third patient despite negative (below 0.6 IU\/ml) HCG assays. The studies show that the mole trophoblast is the principal source of progesterone and the ovaries are a secondary source. Theca lutein cysts are the principal source of 17\u03b1-hydroxyprogesterone.<\/jats:p>","DOI":"10.1530\/acta.0.0710773","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:19:36Z","timestamp":1229375976000},"page":"773-780","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":0,"title":["THE SOURCE OF CIRCULATING PROGESTERONE AND 17\u03b1-HYDROXYPROGESTERONE IN HYDATIDIFORM MOLE"],"prefix":"10.1093","volume":"71","author":[{"given":"Eng Soon","family":"Teoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. P.","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Yusoff","family":"Dawood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"Ratnam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/71\/4\/acta_71_4_014.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/71\/4\/acta_71_4_014.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:18:26Z","timestamp":1676391506000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/71\/4\/773\/6837174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,12]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0710773","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,12]]}}}