{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:56Z","timestamp":1760189036212},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Detailed hormonal studies were performed before, during and after three pregnancies in an untreated patient with adrenocortical hyperfunction due to hyperplasia.<\/jats:p>\n        <jats:p>The patient was clinically characterized by oligomenorrhoea and moderate hirsutism, but showed no signs of virilization or of Cushing's disease. In the <jats:italic>non-pregnant state<\/jats:italic> her 17-ketosteroid excretion was elevated to twice the normal value, the androsterone fraction being moderately and the aetiocholanolone fraction greatly elevated, whereas the excretion of dehydro<jats:italic>epi<\/jats:italic>androsterone was essentially normal. In the non-pregnant state the excretion of 17-ketogenic steroids, tetrahydrocortisol, tetrahydrocortisone, cortisone and tetrahydrocorticosterone was also considerably elevated. On high doses of dexamethasone (8 mg daily) or cortisone (100 mg daily) all fractions of 17-ketosteroids as well as the cortisol metabolites were suppressed to about one-half.<\/jats:p>\n        <jats:p>Without preceding or simultaneous steroid treatment the patient <jats:italic>conceived three times<\/jats:italic>. During all three pregnancies every sign of excessive hormone production ceased. The excretion of 17-ketosteroids in all fractions fell to 20\u201330%, that of 17-ketogenic steroids to between 30% and 35 %, and that of cortisol metabolites to between 5 % and 46 % of the levels found before and after the pregnancies.<\/jats:p>\n        <jats:p>The considerable endocrine activity of the foeto-placental unit may have \"normalized\" the maternal hypothalamic-pituitary-adrenocortical feed-back mechanism, either by suppressing or by altering the sensitivity of the feed-back system. An alternative theory might be an accelerated rate of cortisol metabolism by the liver in the non-pregnant state which is normalized during the last two trimesters of the pregnancies. The findings are being published as a contribution to the elucidation of the endocrinology of pregnancy.<\/jats:p>","DOI":"10.1530\/acta.0.0730105","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:19:36Z","timestamp":1229375976000},"page":"105-116","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":5,"title":["A CASE OF ADRENOCORTICAL HYPERFUNCTION NORMALIZED DURING THE SECOND AND THIRD TRIMESTERS OF THREE PREGNANCIES"],"prefix":"10.1093","volume":"73","author":[{"given":"P. I.","family":"J\u00f8rgensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Sele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/73\/1\/acta_73_1_011.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/73\/1\/acta_73_1_011.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:20:43Z","timestamp":1676391643000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/73\/1\/105\/6837543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0730105","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,5]]}}}