{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T01:30:40Z","timestamp":1695778240106},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p><jats:list list-type=\"order\"><jats:list-item><jats:p>Plasma from 3 subjects with congenital generalized lipodystrophy was filtered on Sephadex G-50, and the fractions obtained were analyzed for immunoreactive insulin (IRI).<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>In one patient (I.T.) plasma was obtained in the course of an iv glucose tolerance test, during which there was a substantial increase of IRI. In the fasting state IRI was recovered as a single peak with an elution volume corresponding to crystalline insulin. Twenty min after the glucose load the insulin immunoreactivity appeared in two peaks, a major peak corresponding to crystalline insulin (\"little\" insulin) and a small peak corresponding to beef pro-insulin (\"big\" insulin). The relative amount of \"big\" insulin remained small during the glucose tolerance test. Twenty min after the glucose load the amount of \"big\" insulin was 4 per cent, whereas 6 per cent was found after 170 min.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>In a second patient (L.S.N.) with a substantially, lower IRI-activity \"big\" insulin was not detected after a glucagon load. Likewise, in a third patient (A.E.) with frank diabetes, studied after the age of puberty, a tolbutamide tolerance test failed to reveal any significant amount of \"big\" insulin.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1530\/acta.0.0730731","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:19:36Z","timestamp":1229375976000},"page":"731-739","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":2,"title":["STUDIES IN CONGENITAL GENERALIZED LIPODYSTROPHY"],"prefix":"10.1093","volume":"73","author":[{"given":"Oddmund","family":"S\u00f6vik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svein","family":"Oseid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"\u00d6yas\u00e6ter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/73\/4\/acta_73_4_013.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/73\/4\/acta_73_4_013.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:21:07Z","timestamp":1676391667000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/73\/4\/731\/6837554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,8]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0730731","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,8]]}}}