{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:02:54Z","timestamp":1756994574742},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Twenty newly diagnosed, but as yet untreated patients of both sexes with classical juvenile diabetes were investigated by determining the mean plasma immunoreactive growth hormone (IRHGH) and urinary IRHGH for a 24 hour period before and during initial insulin treatment.<\/jats:p>\n        <jats:p><jats:list list-type=\"order\"><jats:list-item><jats:p>The plasma IRHGH was significantly higher (0.05 &gt; <jats:italic>P<\/jats:italic> &gt; 0.01) before than during initial insulin treatment.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>During initial insulin treatment, the mean plasma IRHGH was significantly higher (0.01 &gt; <jats:italic>P<\/jats:italic> &gt; 0.001) than in a control group.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>The urinary IRHGH was significantly higher (0.01 &gt; <jats:italic>P<\/jats:italic> &gt; 0.001) before than during insulin treatment.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>The increased urinary IRHGH observed before insulin treatment is thought to be partly due to a defective renal tubular reabsorption of growth hormone.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>No significant correlation was found between the mean blood sugar and plasma or urinary IRHGH either before or during insulin treatment.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1530\/acta.0.0750050","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:19:36Z","timestamp":1229375976000},"page":"50-63","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":8,"title":["IMMUNOREACTIVE GROWTH HORMONE IN PLASMA AND URINE IN JUVENILE DIABETICS BEFORE AND DURING INITIAL INSULIN TREATMENT"],"prefix":"10.1093","volume":"75","author":[{"given":"Kristian F.","family":"Hanssen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/75\/1\/acta_75_1_006.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/75\/1\/acta_75_1_006.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:21:51Z","timestamp":1676391711000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/75\/1\/50\/6837866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0750050","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1]]}}}