{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:09Z","timestamp":1676438589900},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>HGH plasma levels were studied in 45 children with different types of cyanotic and acyanotic congenital heart diseases with and without growth retardation. Median HGH levels in patients with normal height (Group I) were 5.2 ng\/ml (range 0\u201350) and in patients with short stature (Group II) 7.2 ng\/ml (range 0.6\u201350). No difference was found between these groups (\"Z\" = 1.33, <jats:italic>P<\/jats:italic>: non-significant). However on comparing the cyanotic and acyanotic patients regardless of the presence of growth retardation, HGH levels were significantly different (<jats:italic>P<\/jats:italic> &lt; 0.01). The acyanotic group with an oxygen saturation of 94.4 % \u00b1 1.7 (mean \u00b1 <jats:sc>se<\/jats:sc>) had HGH levels of 4.6 \u00b1 0.7 ng\/ml. The cyanotic group with an oxygen saturation of 69.5 % \u00b1 4.4 had HGH levels of 23.3 ng\/ml \u00b1 3.5. An insulin test was performed in 5 patients with high HGH basal levels. Three showed an increase of HGH levels after insulin. In the other 2 patients the HGH levels remained high.<\/jats:p>\n        <jats:p>In conclusion growth hormone deficiency could be ruled out as a possible cause of growth retardation in children with congenital heart disease. It is suggested that hypoxia could induce HGH secretion. Tissue hypoxia and its effect on DNA metabolism could be a factor which regulates HGH production. Hypoxia could also stimulate anaerobic metabolism and the resultant metabolites bring about an increase in HGH release.<\/jats:p>","DOI":"10.1530\/acta.0.0770451","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:19:36Z","timestamp":1229375976000},"page":"451-459","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":5,"title":["LEVELS OF PLASMA GROWTH HORMONE IN CHILDREN WITH CONGENITAL HEART DISEASE"],"prefix":"10.1093","volume":"77","author":[{"given":"Martha","family":"Fahrer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gru\u00f1eiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Rivarola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Bergad\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/77\/3\/acta_77_3_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/77\/3\/acta_77_3_005.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:23:11Z","timestamp":1676391791000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/77\/3\/451\/6838112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,11]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0770451","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,11]]}}}