{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:24:26Z","timestamp":1693916666046},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1975,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>The intravenous infusion of prostaglandin (PG) E<jats:sub>1<\/jats:sub>, E<jats:sub>2<\/jats:sub>, and A<jats:sub>1<\/jats:sub> into normal rats at a dose of 2 \u03bcg\/min significantly lowered plasma insulin levels with a tendency to recovery in the post-infusion period. Whereas PGA<jats:sub>1<\/jats:sub> infusion resulted in a moderate but significant hypoglycaemia, the administration of E-series PGs always produced a hyperglycaemic effect. The interference of PGE<jats:sub>1<\/jats:sub> on insulin response to classical insulinogogues (glucagon, aminophylline, and tolbutamide) was also investigated. The results of these experiments demonstrate that PGE<jats:sub>1<\/jats:sub> exerts an inhibitory action on insulin response to all insulin releasing agents investigated. As regards the haemodynamic effects of PGs, PGE<jats:sub>1<\/jats:sub> and PGE<jats:sub>2<\/jats:sub> lowered the arterial blood pressure by about 20%, while PGA<jats:sub>1<\/jats:sub> was almost completely ineffective. On the other hand, the lowering effect of PGE<jats:sub>1<\/jats:sub> on circulating insulin levels remained unchanged in rats treated with reserpine. These findings thus rule out a sympathetic over-activity secondary to the lowered arterial blood pressure as the mechanism of action of PGE<jats:sub>1<\/jats:sub>. A possible direct interference with the adrenergic receptor system of the pancreatic islets was also ruled out since the inhibitory effect of PGE<jats:sub>1<\/jats:sub> was not overcome by phentolamine pre-treatment.<\/jats:p>","DOI":"10.1530\/acta.0.0790266","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:31:09Z","timestamp":1229376669000},"page":"266-274","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":16,"title":["REDUCTION OF CIRCULATING INSULIN LEVELS DURING THE INFUSION OF DIFFERENT PROSTAGLANDINS IN THE RAT"],"prefix":"10.1093","volume":"79","author":[{"given":"L.","family":"Sacc\u00e0","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Rengo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Pascucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Condorelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/79\/1\/acta_79_1_029.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/79\/1\/acta_79_1_029.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:25:09Z","timestamp":1676391909000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/79\/1\/266\/6838285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0790266","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,5]]}}}