{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T15:30:11Z","timestamp":1695828611842},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1975,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Both serum progesterone and serum unconjugated oestradiol-17\u03b2 (Oe<jats:sub>2<\/jats:sub>) were measured by competitive protein binding assay and radioimmunoassay respectively in 42 cases of unaborted hydatidiform mole. Serum human chorionic gonadotrophin (HCG) was measured by a haemagglutination-inhibition technique. In 26 cases of intact molar pregnancies without theca lutein cysts (TLC), serum progesterone ranged from 18.0 to 289.0 ng\/ml with a mean \u00b1 standard error of the mean (<jats:sc>sem<\/jats:sc>) of 65.9 \u00b1 13.1 ng\/ml; serum Oe<jats:sub>2<\/jats:sub> ranged from 4.0 to 37.0 ng\/ml with a mean \u00b1 <jats:sc>sem<\/jats:sc> of 17.9 \u00b1 1.9 ng\/ml; serum HCG ranged from 60 to 1920 IU\/ml with a mean \u00b1 <jats:sc>sem<\/jats:sc> of 531.5 \u00b1 105.7 IU\/ml. In contrast, 16 cases of intact molar pregnancies with TLC had serum progesterone ranging from 34.1 to 288.0 ng\/ml with a mean \u00b1 <jats:sc>sem<\/jats:sc> of 134.1 \u00b1 2.4 ng\/ml; serum Oe<jats:sub>2<\/jats:sub> ranging from 1.7 to 76.3 ng\/ml with a mean \u00b1 <jats:sc>sem<\/jats:sc> of 31.5 \u00b1 5.3 ng\/ml; serum HCG ranging from 320 to 2560 IU\/ml with a mean \u00b1 <jats:sc>sem<\/jats:sc> 1400 \u00b1 196.2 ng\/ml. The differences between the mean of these three hormones in hydatidiform mole with and without TLC were significant (progesterone: <jats:italic>P<\/jats:italic> &lt; 0.005; Oe<jats:sub>2<\/jats:sub>: <jats:italic>P<\/jats:italic> &lt; 0.0125; HCG: <jats:italic>P<\/jats:italic> &lt; 0.005). There was a significant correlation between serum HCG and serum Oe<jats:sub>2<\/jats:sub> (coefficient of correlation r =+0.3565, <jats:italic>P<\/jats:italic> &lt; 0.0125) and between serum Oe<jats:sub>2<\/jats:sub> and serum progesterone (r = +0.3787, <jats:italic>P<\/jats:italic> &lt; 0.0125). There was no significant difference in the mean levels of serum progesterone, Oe<jats:sub>2<\/jats:sub> and HCG in hydatidiform mole with and without subsequent malignant sequelae. The mean ratios of Oe<jats:sub>2<\/jats:sub>\/progesterone were essentially similar in moles with and without TLC and with and without malignant sequelae. The significance of these findings are discussed.<\/jats:p>","DOI":"10.1530\/acta.0.0790729","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:31:09Z","timestamp":1229376669000},"page":"729-739","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["THE SIGNIFICANCE OF SERUM PROGESTERONE AND SERUM UNCONJUGATED OESTRADIOL-17\u03b2 IN UNABORTED HYDATIDIFORM MOLE"],"prefix":"10.1093","volume":"79","author":[{"given":"M. Yusoff","family":"Dawood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/79\/4\/acta_79_4_012.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/79\/4\/acta_79_4_012.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:25:26Z","timestamp":1676391926000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/79\/4\/729\/6838239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,8]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0790729","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,8]]}}}