{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:42:34Z","timestamp":1767843754023,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n<jats:p>Plasma Oe<jats:sub>2<\/jats:sub> concentration was measured by radioimmunoassay in patients with premature thelarche, with precocious puberty and in 29 normal controls. The mean plasma Oe<jats:sub>2<\/jats:sub> was 1.5 pg\/ml (0\u20137.2) in normal prepubertal girls, 23.8 \u00b1 17.8 (<jats:sc>sd<\/jats:sc>) in pubertal girls, 50.2 (\u00b1 19.4) in the follicular phase, and 94.2 (\u00b1 19.5) in the luteal phase of normal adult females. Ten girls with premature thelarche had a mean of 7.7 \u00b1 6.6 pg\/ml. Three of them showed higher values than the other 7, suggesting that in these cases, elevated levels of plasma Oe<jats:sub>2<\/jats:sub> might have played a role in the development of breast tissue. Ten untreated girls with idiopathic precocious sexual development had a mean of 51.6 \u00b1 42.9 pg\/ml while 6 patients treated with 150 mg per week of medroxyprogesterone acetate had a mean of 11.4 \u00b1 2.5 pg\/ml. Two patients with Down's syndrome, hypothyroidism and sexual precocity had plasma Oe<jats:sub>2<\/jats:sub> of 144 and 31.5 which fell to 24.7 and 8 pg\/ml, respectively, after thyroid replacement. One girl with a granulosa cell tumour had a basal value of 304 pg\/ml and a concentration of 27 pg\/ml after surgery.<\/jats:p>","DOI":"10.1530\/acta.0.0810351","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:31:09Z","timestamp":1229376669000},"page":"351-361","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":22,"title":["PLASMA CONCENTRATION OF OESTRADIOL-17\u03b2 IN PREMATURE THELARCHE AND IN DIFFERENT TYPES OF SEXUAL PRECOCITY"],"prefix":"10.1093","volume":"81","author":[{"given":"Maria Eugenia","family":"Escobar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"Rivarola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Bergad\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/81\/2\/acta_81_2_011.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/81\/2\/acta_81_2_011.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:27:08Z","timestamp":1676392028000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/81\/2\/351\/6838811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0810351","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,2]]}}}