{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T23:21:13Z","timestamp":1697671273245},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n<jats:p>The effects of subcutaneous administration of steroids from the androstene, 5\u03b1-androstane, 5\u03b2-androstane, oestrene and oestratriene series on serum levels of LH and FSH and on ventral prostate weights were investigated in gonadectomized, adult male rats. Each steroid was administered for seven days in a standard dose of 100 \u03bcg per 100 g body weight per day. 5\u03b1-Androstanes disubstituted with oxygen in the positions 3 (3-keto or 3\u03b1-hydroxy) and 17 (17-keto or 17\u03b2-hydroxy) were effective in suppressing either one or both serum gonadotrophins. 5\u03b2-Androstanes and androstenes exhibited very little inhibitory effect in this respect. Potent suppression of serum gonadotrophins was observed following treatment with oestratrienes, the presence of only a phenolic A-ring in these oestrogens appeared sufficient for such suppression. 3 or 3\u03b2 and 17 or 17\u03b2 disubstituted (keto or hydroxyl) androstenes could entirely or partly prevent ventral prostate weight decrease post-gonadectomy. 5\u03b1-Androstane-3\u03b1,17\u03b2-diol, 5\u03b1-androstane-3\u03b1,11\u03b2,17\u03b2-triol and 5\u03b1-androstan-17\u03b2-ol-3-one were most potent, while 5\u03b2-androstanes and oestratrienes had no effect on this decrement. Regulatory processes by steroids at the hypothalamic-pituitary and at the ventral prostate level were not parallel.<\/jats:p>\n<jats:p>The results indicate, however, that 3 or 3\u03b1 and 17 disubstituted (keto or hydroxyl) 5\u03b1-reduced testosterone metabolites, of which 5\u03b1-androstan-17\u03b2-ol-3-one might be the principal one, are the main steroids directing androgenic regulation at both organ systems tested in the mature male rat.<\/jats:p>","DOI":"10.1530\/acta.0.0830201","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:31:09Z","timestamp":1229376669000},"page":"201-210","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":10,"title":["EFFECTS OF ANDROSTENES, 5\u03b1-ANDROSTANES, 5\u03b2-ANDROSTANES, OESTRENES AND OESTRATRIENES ON SERUM GONADOTROPHIN LEVELS AND VENTRAL PROSTATE WEIGHTS IN GONADECTOMIZED, ADULT MALE RATS"],"prefix":"10.1093","volume":"83","author":[{"given":"H. L.","family":"Verjans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. B.","family":"Eik-Nes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/83\/1\/acta_83_1_022.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/83\/1\/acta_83_1_022.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:02Z","timestamp":1676392082000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/83\/1\/201\/6838950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,9]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0830201","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,9]]}}}