{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:05:21Z","timestamp":1762160721798,"version":"build-2065373602"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n<jats:p>The secretion of iodothyronines from the normal human thyroid gland was assessed by radioimmunoassay analyses of the concentrations of thyroxine (T<jats:sub>4<\/jats:sub>), 3,5,3\u2032-triiodothyronine (T<jats:sub>3<\/jats:sub>) and 3,3\u2032,5\u2032-triiodothyronine (reverse T<jats:sub>3<\/jats:sub>, rT<jats:sub>3<\/jats:sub>) in thyroid venous and peripheral venous blood. The subjects studied were euthyroid patients undergoing parathyroid surgery. Measurements were carried out both under apparently normal conditions, following peroral T<jats:sub>3<\/jats:sub> pre-treatment, and before and after acute administration of TSH into a thyroid artery. In the control subjects, significant gradients between thyroid venous and peripheral venous concentrations were recorded both for T<jats:sub>4<\/jats:sub>, T<jats:sub>3<\/jats:sub> and rT<jats:sub>3<\/jats:sub>, suggesting that all three iodothyronines are secreted by the normal human thyroid. T<jats:sub>3<\/jats:sub> pre-treatment seemed to reduce this secretion, and acute administration of TSH promoted rapid, marked, and concomitant increments in the thyroid venous concentrations of all three iodothyronines. Hence, it appears that not only T<jats:sub>4<\/jats:sub> but also T<jats:sub>3<\/jats:sub> and rT<jats:sub>3<\/jats:sub> are secreted by the normal human thyroid gland, and that TSH stimulates the secretion of all three iodothyronines. On the other hand, calculations of the relative secretion rates yielded the relation T<jats:sub>4<\/jats:sub>:T<jats:sub>3<\/jats:sub>:rT<jats:sub>3<\/jats:sub> as 85:9:1. This indicates that, in euthyroid subjects, most of T<jats:sub>3<\/jats:sub>, and almost all of rT<jats:sub>3<\/jats:sub>, is produced by extrathyroidal conversion of T<jats:sub>4<\/jats:sub> and not by direct thyroidal secretion.<\/jats:p>","DOI":"10.1530\/acta.0.0840281","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:31:09Z","timestamp":1229376669000},"page":"281-289","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":11,"title":["SECRETION OF THYROXINE, 3,5,3\u2032-TRIIODOTHYRONINE AND 3,3\u20325\u2032-TRIIODOTHYRONINE IN EUTHYROID MAN"],"prefix":"10.1093","volume":"84","author":[{"given":"U.","family":"Westgren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Melander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ingemansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Burger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tibblin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Wa\u00b0hlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/84\/2\/acta_84_2_006.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/84\/2\/acta_84_2_006.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:31Z","timestamp":1676392111000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/84\/2\/281\/6840083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0840281","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"type":"print","value":"0804-4643"},{"type":"electronic","value":"1479-683X"}],"subject":[],"published":{"date-parts":[[1977,2]]}}}