{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:10:24Z","timestamp":1761955824355,"version":"build-2065373602"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n<jats:p>Blood samples for determination of serum total and free reverse triiodothyronine (rT<jats:sub>3<\/jats:sub>), triiodothyronine (T<jats:sub>3<\/jats:sub>) and thyroxine (T<jats:sub>4<\/jats:sub>) were obtained daily in 6 previously untreated thyrotoxic patients during periods of propylthiourazil (PTU) (600 mg per day) or methimazol (MMI) (45 mg per day) administration.<\/jats:p>\n<jats:p>PTU induced about 60 per cent increase in both total and free serum rT<jats:sub>3<\/jats:sub>. This was accompanied by a rapid decrease in serum T<jats:sub>3<\/jats:sub> and a more gradual decline in serum T<jats:sub>4<\/jats:sub>. MMI administration to untreated patients was followed by a gradual parallel decrease in rT<jats:sub>3<\/jats:sub>, T<jats:sub>3<\/jats:sub> and T<jats:sub>4<\/jats:sub>. Turn from PTU to MMI produced a rapid decrease in serum rT<jats:sub>3<\/jats:sub> and increase in serum T<jats:sub>3<\/jats:sub> in all 6 patients. The relative variations in the free and total concentrations of iodothyronines were practically identical.<\/jats:p>\n<jats:p>The increase in serum rT<jats:sub>3<\/jats:sub> after PTU is most likely explained either by enhanced deiodination of T<jats:sub>4<\/jats:sub> to rT<jats:sub>3<\/jats:sub> or by an inhibitory effect of PTU on rT<jats:sub>3<\/jats:sub> degradation.<\/jats:p>","DOI":"10.1530\/acta.0.0870088","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:31:09Z","timestamp":1229376669000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["OPPOSITE VARIATIONS IN SERUM T3 AND REVERSE T3 DURING PROPYLTHIOURACIL TREATMENT OF THYROTOXICOSIS"],"prefix":"10.1093","volume":"87","author":[{"given":"Peter","family":"Laurberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen","family":"Weeke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/87\/1\/acta_87_1_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/87\/1\/acta_87_1_010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:29:57Z","timestamp":1676392197000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/87\/1\/88\/6802781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0870088","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"type":"print","value":"0804-4643"},{"type":"electronic","value":"1479-683X"}],"subject":[],"published":{"date-parts":[[1978,1]]}}}