{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T12:03:12Z","timestamp":1697803392451},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>The evolution of the thyrotrophin (TSH) response after 400 \u03bcg thyrotrophin-releasing hormone (TRH) was investigated during recovery of hypothyroidism.<\/jats:p>\n        <jats:p>In 14 myxoedematous patients, replacement therapy with thyroxine (T<jats:sub>4<\/jats:sub>) caused characteristic changes. Before treatment a relatively blunted pattern with m\u0394TSH<jats:sup>1<\/jats:sup>) of 51.2 \u00b1 30.6 mU\/1 was found. Two and 4 weeks after treatment an enhanced response was evolved with values for m\u0394TSH of 87.7 \u00b1 43.4 and 96.0 \u00b1 48.0 mU\/1 (<jats:italic>P<\/jats:italic> &lt; 0.02 respectively &lt; 0.01). Comparison of the TSH curve showed significant increases in \u0394TSH during the first 4 weeks of treatment at 20, 40 and 60 min compared to corresponding measurements in the basal state.<\/jats:p>\n        <jats:p>In 17 overtreated hyperthyroid patients with mild, mostly chemical hypothyroidism the influence of T<jats:sub>4<\/jats:sub> replacement on TSH responses at different TSH levels was studied. At the stage of mild TSH elevation (3\u201310 mU\/1) m\u0394TSH before and during substitution were 12.6 \u00b1 6.7 and 25.9 \u00b1 15.3 mU\/1, respectively (<jats:italic>P<\/jats:italic> &lt; 0.01). Moderate TSH elevation (10\u201325 mU\/1) was accompanied by m\u0394TSH of 25.4 \u00b1 13.4, respectively 44.5 \u00b1 22.9 mU\/1 (<jats:italic>P<\/jats:italic> &lt; 0.01) while high TSH values (&gt; 26 mU\/1) had responses of 39.1 \u00b1 16.0 and 92.5 \u00b1 22.0 mU\/1 (<jats:italic>P<\/jats:italic> &lt; 0.001). In these patients the initial blunting of TSH responses could not be attributed to the foregoing toxicosis, since follow up during 6\u201315 weeks of protracted hypothyroidism did not show any tendency to enhancement of relative release (% m\u0394TSH).<\/jats:p>\n        <jats:p>These findings suggest that in the early stage of replacement therapy of hypothyroidism, either pituitary TSH is accumulating or that endogenous TRH is declining.<\/jats:p>","DOI":"10.1530\/acta.0.0890303","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:31:09Z","timestamp":1229376669000},"page":"303-315","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["EFFECTS OF SUBSTITUTION WITH THYROXINE ON THE THYROTROPHIN (TSH) RESPONSE TO THYROTROPHIN-RELEASING HORMONE (TRH) IN SEVERE PRIMARY MYXOEDEMA AND IN MILD HYPOTHYROIDISM FOLLOWING PROLONGED THYROSTATIC THERAPY"],"prefix":"10.1093","volume":"89","author":[{"given":"H. R. A.","family":"Fischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. H. L.","family":"Hackeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Schopman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Silberbusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/89\/2\/acta_89_2_011.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/89\/2\/acta_89_2_011.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:31:05Z","timestamp":1676392265000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/89\/2\/303\/6802931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,10]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0890303","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,10]]}}}