{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:11Z","timestamp":1676438591529},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>The pancreatic glucagon (IRG) secretion pattern was studied during a 2 h glucose infusion test (12 mg\/kg\/min) in 21 controls as well as in 44 subjects showing different degrees of carbohydrate intolerance.<\/jats:p>\n        <jats:p>The fasting IRG levels increased significantly from controls (98 \u00b1 7.6 pg\/ml) to chemical (144 \u00b1 9 pg\/ml) and mild maturity-onset-type diabetics (166 \u00b1 12.2 pg\/ml).<\/jats:p>\n        <jats:p>During artificial hyperglycaemia the glucagon concentrations decreased slightly in all groups, but they remained at a higher level in early and overt diabetics<jats:sup>1)<\/jats:sup>. The molar IRI-IRG ratios have been found to be diminished in patients displaying a disturbed carbohydrate tolerance. There was not any correlation between insulin and glucagon concentrations in the blood.<\/jats:p>\n        <jats:p>The findings suggest that abnormalities of alpha cell function may be present in early and overt diabetes independent of beta cell responsiveness. The causal relationship of A and B cell function in glucose intolerant subjects has to be cleared in follow-up studies.<\/jats:p>","DOI":"10.1530\/acta.0.0890329","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:31:09Z","timestamp":1229376669000},"page":"329-338","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":2,"title":["REGULATION OF PANCREATIC GLUCAGON SECRETION DURING A CONTINUOUS GLUCOSE INFUSION IN EARLY AND OVERT DIABETICS"],"prefix":"10.1093","volume":"89","author":[{"given":"B.","family":"Schulz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Witt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Rjasanowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Heinke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Bibergeil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/89\/2\/acta_89_2_014.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/89\/2\/acta_89_2_014.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:31:06Z","timestamp":1676392266000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/89\/2\/329\/6802936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,10]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0890329","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,10]]}}}