{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:33:26Z","timestamp":1760546006339},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Male Sprague-Dawley rats were given graded doses of methylmercaptoimidazole (MMI), propylthiouracil (PTU), KClO<jats:sub>4<\/jats:sub> or KI in drinking water for 4 days, or the lowest effective dose of each drug for various times. The rats were sacrificed at 1\u20132 p. m. and serum T<jats:sub>3<\/jats:sub>, T<jats:sub>4<\/jats:sub> and TSH concentrations were measured by radioimmunoassays. It was found that administration of 5 mg\/l of MMI, 10 mg\/l of PTU and 100 mg\/l of KClO<jats:sub>4<\/jats:sub> for 4\u201314 days induced a transient rise in serum TSH and a fall in serum T<jats:sub>3<\/jats:sub> or T<jats:sub>4<\/jats:sub> or in both. The effects of KI were not consistent. In another series of experiments, PTU (10 mg\/l) was given in drinking water for 4 days, and then graded doses of T<jats:sub>3<\/jats:sub> or T<jats:sub>4<\/jats:sub> were given iv, or 100 ng of TRH was injected into a tail vein, or the animals were exposed to 4\u00b0C for 30 min. The initial high TSH levels were further increased by TRH and cold and decreased by T<jats:sub>3<\/jats:sub> and T<jats:sub>4<\/jats:sub>. The PTU-treated animals had goitres after 4 days. We infer that low doses, that is to say 10\u2013100 times lower than previously described, of antithyroid drugs induce a hypothyroidism characterized by an increased TSH level and a decreased serum T<jats:sub>3<\/jats:sub> or T<jats:sub>4<\/jats:sub> level or both. A 4 days' treatment with PTU (10 mg\/l in tap water) is a suitable tool for studying the effect of various conditions on TSH secretion.<\/jats:p>","DOI":"10.1530\/acta.0.0910271","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"271-281","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":20,"title":["EFFECTS OF METHYLMERCAPTOIMIDAZOLE (MMI), PROPYLTHIOURACIL (PTU), POTASSIUM PERCHLORATE (KClO4) AND POTASSIUM IODIDE (KI) ON THE SERUM CONCENTRATIONS OF THYROTROPHIN (TSH) AND THYROID HORMONES IN THE RAT"],"prefix":"10.1093","volume":"91","author":[{"given":"P. T.","family":"M\u00e4nnist\u00f6","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ranta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lepp\u00e4luoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/91\/2\/acta_91_2_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/91\/2\/acta_91_2_010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:32:08Z","timestamp":1676392328000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/91\/2\/271\/6803197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,6]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0910271","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,6]]}}}