{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:49Z","timestamp":1676438629339},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Effects of dinitrophenol (DNP), salicylate, diphenylhydantoin (DPH) and heparin on thyroid-hormone binding by human liver cytosol were studied using Pevikon thin-layer electrophoresis. Thyroxine (T<jats:sub>4<\/jats:sub>) binding by the major cytosol T<jats:sub>4<\/jats:sub>-binding protein, hT<jats:sub>4<\/jats:sub>-2, was significantly depressed with these drugs, and the displaced T<jats:sub>4<\/jats:sub> was bound by another cytosol binding protein, hT<jats:sub>4<\/jats:sub>-1. Triiodothyronine (T<jats:sub>3<\/jats:sub>) binding by the major cytosol T<jats:sub>3<\/jats:sub>-binding protein, hT<jats:sub>3<\/jats:sub>-2, was significantly decreased with DPH and heparin, but not with DNP and salicylate. Comparative studies using human serum indicated that T<jats:sub>4<\/jats:sub> binding by serum T<jats:sub>i<\/jats:sub>-binding prealbumin (TBPA) was inhibited with DNP and salicylate, and that binding of T<jats:sub>4<\/jats:sub> and T<jats:sub>3<\/jats:sub> by serum T<jats:sub>4<\/jats:sub>-binding globulin (TBG) was decreased only with DPH. The results obtained indicate that these drugs inhibit thyroid-hormone binding by the liver cytosol binding proteins for T<jats:sub>4<\/jats:sub> and T<jats:sub>3<\/jats:sub>, and that the displaced hormones may be responsible for changes in free hormone levels in serum, and within the cells, and for the accelerated turnover of hormones.<\/jats:p>","DOI":"10.1530\/acta.0.0920277","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"277-285","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":0,"title":["INHIBITORY EFFECT OF CERTAIN DRUGS ON THYROID HORMONE BINDING BY HUMAN LIVER CYTOSOL"],"prefix":"10.1093","volume":"92","author":[{"given":"Satoshi","family":"Hamada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Nishimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/92\/2\/acta_92_2_008.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/92\/2\/acta_92_2_008.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:32:55Z","timestamp":1676392375000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/92\/2\/277\/6803324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,10]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0920277","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,10]]}}}