{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:03:41Z","timestamp":1761512621125},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Progesterone increases urinary sodium excretion at least in part by competition for renal mineralocorticoid receptors. In contrast, synthetic progestagens do not increase sodium excretion or even cause a slight sodium retention. We therefore compared the ability of progesterone and 12 progesterone like compounds to displace [<jats:sup>3<\/jats:sup>H] aldosterone from binding at cytoplasmic mineralocorticoid receptors in rat kidney. All synthetic progesteronelike steroids were less active than progesterone in competing with [<jats:sup>3<\/jats:sup>H]aldosterone for the receptor binding: progesterone 100 %, 11\u03b2-OH progesterone 50 %, 17 a OH-progesterone 24 % and 16 \u03b1-methylprogesterone 3 %. Derivates of 17 \u03b1 OH-progesterone (medrogestone 5 %, dydrogestone 4 %, medroxy progesterone-acetate 2 % and chlormadinone-acetate 0.5 %) were more potent than 19-nor-testosterone derivates: ethisterone 1 %, norethisterone &lt; 1 %, norethindrone &lt; 1 %, norethylnodrel &lt; 1 %, and ethynodiol-diacetate &lt; 1 %. The decreased affinity of synthetic progestins for mineralocorticoid receptors explains in part the lack of natriuretic activity of these compounds.<\/jats:p>","DOI":"10.1530\/acta.0.0920560","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"560-567","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":19,"title":["INTERACTION OF SYNTHETIC PROGESTAGENS WITH RENAL MINERALOCORTICOID RECEPTORS"],"prefix":"10.1093","volume":"92","author":[{"given":"G.","family":"Wambach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Kern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/92\/3\/acta_92_3_019.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/92\/3\/acta_92_3_019.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:33:05Z","timestamp":1676392385000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/92\/3\/560\/6803367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,11]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0920560","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,11]]}}}