{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:53Z","timestamp":1760189033281},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,2]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>Homogenates of normal or cryptorchid, human testes were incubated with [<jats:sup>3<\/jats:sup>H]testosterone and a NADPH-generating system. [<jats:sup>3<\/jats:sup>H]4-andostene,7\u03b1,17\u03b2-diol-3-one (7\u03b1-OH-testosterone) was isolated and identified from such incubations. To our knowledge this is the first demonstration that 7\u03b1-OH-testosterone is a metabolite of testosterone in the human testis. 4-Andro-stene,6\u03b2,17\u03b2-diol-3-one (6\u03b2-OH-testosterone) and 4-androstene,16\u03b1,17\u03b2-diol-3-one (16\u03b1-OH-testosterone) were also identified as testosterone metabolites. The specific activity of both testosterone 6\u03b2- and 16\u03b1-hydroxylase was higher than that of 7\u03b1-hydroxylase. Pre-pubertal or cryptorchid human testis tissues seem in our study to have higher testosterone 6\u03b2- and 7\u03b1-hydroxylase activity than normal adult testis tissue.<\/jats:p>","DOI":"10.1530\/acta.0.0930243","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"243-249","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":7,"title":["Hydroxylation of testosterone in the human testis Identification of 4-androstene,7\u03b1,17\u03b2-diol-3-one (7\u03b1-hydroxytestosterone) as a metabolite of testosterone"],"prefix":"10.1093","volume":"93","author":[{"given":"A.","family":"Sunde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tveter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. B.","family":"Eik-Nes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/93\/2\/acta_93_2_019.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/93\/2\/acta_93_2_019.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:33:25Z","timestamp":1676392405000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/93\/2\/243\/6803523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0930243","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,2]]}}}