{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T18:21:53Z","timestamp":1699726913023},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,3]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>Serum prolactin (Prl) levels in basal conditions and those following metoclopramide administration (10 mg orally) were determined in 10 women with Cushing's syndrome, 9 patients bilaterally adrenalectomized for adrenal hyperplasia without clinical evidence of a pituitary tumour, and one after adrenal adenoma removal, 8 women with Nelson's syndrome and 12 normal subjects. Blood samples were taken at 1 and 2 h after metoclopramide administration.<\/jats:p>\n<jats:p>In patients with hyperadrenocorticism the Prl responsiveness was reduced compared into the bilaterally adrenalectomized patients and the control group. In the bilaterally adrenalectomized patients without features of a pituitary adenoma, Prl responses to metoclopramide were significantly higher than those in the remaining subjects under investigation. In the patients with Nelson's syndrome mean baseline Prl was higher than that in the other groups studied; serum Prl responses to metoclopramide were significantly lower than those in the bilaterally adrenalectomized patients with no evidence of a pituitary tumour.<\/jats:p>\n<jats:p>These results indicate that: 1) hypercortisolaemia of Cushing's disease diminishes Prl responses to metoclopramide, 2) the elimination of hypercortisolaemia by adrenalectomy results in a hyperresponsiveness of serum Prl to metoclopramide, 3) the development of Nelson's tumours is associated with increased baseline Prl and with significantly lower Prl responses to metoclopramide compared with those found in the other patients adrenalectomized for Cushing's syndrome, without clinical evidence of a pituitary adenoma.<\/jats:p>","DOI":"10.1530\/acta.0.0930351","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"351-355","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["Serum prolactin responses to metoclopramide in Cushing's syndrome and Nelson's syndrome"],"prefix":"10.1093","volume":"93","author":[{"given":"Anna A.","family":"Kasperlik-Zaluska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Jeske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/93\/3\/acta_93_3_015.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/93\/3\/acta_93_3_015.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:33:30Z","timestamp":1676392410000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/93\/3\/351\/6803509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0930351","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,3]]}}}