{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T22:14:44Z","timestamp":1698012884876},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,4]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>The function of the thyroid pituitary axis was investigated in 8 anencephalic infants with no hypothalamus.<\/jats:p>\n<jats:p>Thyrotrophin (TSH), thyroxine (T<jats:sub>4<\/jats:sub>), 3,5,3\u2032-triiodothyronine (T<jats:sub>3<\/jats:sub>) and 3,3,\u20325\u2032-triiodothyronine (reverse T<jats:sub>3<\/jats:sub>, rT<jats:sub>3<\/jats:sub>) were measured in the cord blood in 5 cases and during the first 4 h of life in 3 cases, TSH response to synthetic thyrotrophin-releasing hormone (TRH) (200 \u03bcg iv) was carried out in two cases and thyroid hormone response to bovine TSH (5 IU iv) was evaluated in 3 cases.<\/jats:p>\n<jats:p>The following results were obtained:<\/jats:p>\n<jats:p>1) The pituitary gland was found in all infants and the thyroid was normal both grossly and by microscopic sections.<\/jats:p>\n<jats:p>2) TSH levels at birth were normal but there was no spontaneous post-delivery surge.<\/jats:p>\n<jats:p>3) T<jats:sub>4<\/jats:sub> and T<jats:sub>3<\/jats:sub> values at delivery were within normal range, but no T<jats:sub>3<\/jats:sub> increase was present after birth. rT<jats:sub>3<\/jats:sub> levels at birth were higher than normal in 3 cases.<\/jats:p>\n<jats:p>4) Administration of TRH caused a marked and rapid TSH release.<\/jats:p>\n<jats:p>5) Thyroid hormone response to TSH was normal.<\/jats:p>\n<jats:p>The present findings suggest that in the anencephalic foetus both pituitary TSH-secreting cells and the thyroid gland do develop despite the absence of the hypothalamus and are able to function if adequately stimulated.<\/jats:p>","DOI":"10.1530\/acta.0.0930396","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"396-401","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["Thyroid-pituitary function in eight anencephalic infants"],"prefix":"10.1093","volume":"93","author":[{"given":"S.","family":"Grasso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Filetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mazzone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Pezzino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Vigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Vigneri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/93\/4\/acta_93_4_003.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/93\/4\/acta_93_4_003.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:33:32Z","timestamp":1676392412000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/93\/4\/396\/6803558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0930396","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,4]]}}}