{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:47:19Z","timestamp":1759938439462},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,5]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>Clomiphene citrate was administered at a dose of 50 mg\/day for 3 months to 29 boys with delayed puberty, 15 in a stage of early puberty (group 1) and 14 in stages of mid puberty (group 2). In both groups a significant acceleration in the advancement of pubertal signs was noted in the 6-month period following initiation of therapy as compared to a non-treated control group. A significant rise in the mean (\u00b1 <jats:sc>sd<\/jats:sc>) basal plasma LH levels, from 1.0 \u00b1 0.4 to 2.7 \u00b1 2.2 mU\/ml in group 1 (<jats:italic>P<\/jats:italic> &lt; 0.05) and from 1.0 \u00b1 0.6 to 2.2 \u00b1 1.7 mU\/ml in group 2 (<jats:italic>P<\/jats:italic> &lt; 0.05) was observed following the treatment period with clomiphene. Concomitantly there was a rise of the mean basal plasma FSH level from 1.1 \u00b1 0.4 to 2.0 \u00b1 1.5 mU\/ml in group 1 (<jats:italic>P<\/jats:italic> \u00b1 0.05) and from 1.9 \u00b1 1.6 to 3.4 \u00b1 3.0 mU\/ml in group 2 (<jats:italic>P<\/jats:italic> &lt; 0.02). The mean LH peak response to an iv bolus of LRH (50 \u03bcg\/m<jats:sup>2<\/jats:sup> iv) rose from 8.3 \u00b1 4.2 to 13.0 \u00b1 5.3 mU\/ml in group 1 (<jats:italic>P<\/jats:italic> &lt; 0.05) and from 9.2 \u00b1 5.8 to 12.6 \u00b1 6.8 mU\/ml in group 2 (NS). The mean peak plasma FSH response to LRH rose from 2.0 \u00b1 0.6 to 5.9 \u00b1 4.2 mU\/ml in group 1 (<jats:italic>P<\/jats:italic> &lt; 0.05) and from 4.3 \u00b1 4.0 to 7.0 \u00b1 6.8 mU\/ml in group 2 (NS).<\/jats:p>\n<jats:p>Clomiphene therapy caused a rise of the basal plasma testosterone level from 68 \u00b1 53 to 313 \u00b1 270 ng\/100 ml in group 1 (<jats:italic>P<\/jats:italic> &lt; 0.01) and from 103 \u00b1 67 to 392 \u00b1 248 ng\/100 ml in group 2 (<jats:italic>P<\/jats:italic> &lt; 0.01). The plasma testosterone response to one hCG stimulation (5000 U im), tested in 4 boys immediately before and after the 3-month period of clomiphene administration revealed an increase in both the basal and the peak testosterone levels (<jats:italic>P<\/jats:italic> &lt; 0.05 and <jats:italic>P<\/jats:italic> &lt; 0.001, respectively).<\/jats:p>\n<jats:p>A standard clomiphene test consisting of the administration of 100\u2013200 mg\/day clomiphene citrate for 8 days was performed in 8 boys before initiation of clomiphene treatment for the 3-month period. In 4, including 2 boys in an early stage of puberty, there was a suppression of the basal level of gonadotrophins and their response to synthetic LRH. The other 4 boys, all of them in stages of mid-puberty, showed an increase in the basal and peak plasma gonadotrophin levels following LRH stimulation. In all 8 boys there was a significant rise of the basal plasma testosterone level. Despite the varying response to the short clomiphene test in these 8 boys, all gave a good response to the prolonged administration of clomiphene citrate. It was concluded that treatment with small doses of clomiphene citrate for a period of 3 months induces an acceleration of puberty in boys with delayed or slowlyprogressing puberty, once the stage of initiation of puberty has been passed.<\/jats:p>","DOI":"10.1530\/acta.0.0940117","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"117-125","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":3,"title":["Acceleration of puberty in boys with delayed puberty by clomiphene citrate. A clinical and laboratory study"],"prefix":"10.1093","volume":"94","author":[{"given":"Zvi","family":"Dickerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Prager-Lewin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osnat","family":"Lahmy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Laron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/94\/1\/acta_94_1_017.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/94\/1\/acta_94_1_017.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:33:46Z","timestamp":1676392426000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/94\/1\/117\/6803606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0940117","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,5]]}}}