{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:38:18Z","timestamp":1760189898170},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,12]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>Measurement of serum triiodothyronine (T<jats:sub>3<\/jats:sub>), thyroxine (T<jats:sub>4<\/jats:sub>), free triiodothyronine (FT<jats:sub>3<\/jats:sub>), free thyroxine (FT<jats:sub>4<\/jats:sub>), thyroxine-binding-globulin (TGB), antithyroglobulin antibodies (anti-hTg), thyroid <jats:sup>131<\/jats:sup>I uptake and scanning was performed on 12 patients during the early phase of subacute thyroiditis. Serum thyrotropin (TSH) was measured during baseline conditions and following administration of synthetic thyrotropin-releasing-hormone (TRH). The stimulation with exogenous TSH was performed on 7 subjects. <jats:sup>131<\/jats:sup>I uptake was depressed in all patients including those with solitary nodules. Free and total hormone concentrations were elevated in the three cases with diffuse gland involvement, whereas an increase of T<jats:sub>3<\/jats:sub> alone was present in 3 patients with unilobar involvement. In the latter group and in the 2 patients with a nodular form T<jats:sub>4<\/jats:sub>, FT<jats:sub>3<\/jats:sub> and FT<jats:sub>4<\/jats:sub> levels were within normal limits. Interruption of the pituitary-thyroid feed-back mechanism with absence of thyrotropin response to TRH occurred in 11 patients, independent of whether thyroid hormone concentrations were elevated or normal. In one patient only with unilateral involvement, TSH responsiveness to TRH was normal while <jats:sup>131<\/jats:sup>I uptake was not raised by exogenous TSH, indicating diffuse cellular damage. The normal values of FT<jats:sub>3<\/jats:sub> and FT<jats:sub>4<\/jats:sub> found in patients with normal T<jats:sub>3<\/jats:sub> and T<jats:sub>4<\/jats:sub> levels seem to exclude the possibility that the free hormones are responsible for the interrupted feed-back which represents the main cause of suppressed iodine uptake. However, it is possible that the pituitary-thyroid axis is responding to transient or light increases of free and total T<jats:sub>3<\/jats:sub> and T<jats:sub>4<\/jats:sub> still within their 'normal range'.<\/jats:p>","DOI":"10.1530\/acta.0.0950479","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"479-484","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":0,"title":["Alteration of thyroid function in the early stage of subacute thyroiditis"],"prefix":"10.1093","volume":"95","author":[{"given":"G.","family":"Madeddu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Langer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Costanza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Casu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Arras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Campus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/95\/4\/acta_95_4_007.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/95\/4\/acta_95_4_007.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:10:14Z","timestamp":1676391014000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/95\/4\/479\/6804092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0950479","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,12]]}}}