{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:23Z","timestamp":1676438603846},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,8]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>Serum 3'-monoiodothyronine (3'-T<jats:sub>1<\/jats:sub>) levels were estimated by means of a specific radioimmunoassay (RIA) preceded by an ethanol extraction. The recovery of 3'-T<jats:sub>1<\/jats:sub> was in mean (\u00b1 <jats:sc>sem<\/jats:sc>) 110 \u00b1 9%, and the lower detection limit was 23 pmol\/l. Serum levels of 3'-T<jats:sub>1<\/jats:sub> in 34 euthyroid healthy subjects were (median (range)) 55 pmol\/l (&lt;23-168 pmol\/l), in 13 hyperthyroid patients 133 pmol\/l (70-265 pmol\/l) (<jats:italic>P<\/jats:italic> &lt; 0.01) and in 13 hypothyroid patients &lt;23 pmol\/l (&lt;23-68 pmol\/l) (<jats:italic>P<\/jats:italic> &lt;0.01). In 11 patients with chronic renal failure serum 3'-T<jats:sub>1<\/jats:sub> levels were highly increased 285 pmol\/l (115-1538 pmol\/l) (<jats:italic>P<\/jats:italic> &lt; 0.01) and correlated inversely to creatinine clearance (R = \u22120.68, <jats:italic>P<\/jats:italic> &lt; 0.05). In patients with liver cirrhosis serum 3'-T<jats:sub>1<\/jats:sub> levels were unaffected, whereas in 19 patients with endogenous depression studied before and after recovery from the depression serum levels decreased from 70 pmol\/l (&lt; 23-248 pmol\/l) to 30 pmol\/l (&lt;23-95 pmol\/l (<jats:italic>P<\/jats:italic> &lt; 0.01). Administration of propranolol 40 mg b. i. d. for 2 weeks did not affect serum 3'-T<jats:sub>1<\/jats:sub> levels. The study shows that 3'-T<jats:sub>1<\/jats:sub> is present in serum from euthyroid man and varies with thyroid function. Further, it is suggested that 3'-T<jats:sub>1<\/jats:sub> in contrast to other iodothyronines primarily is eliminated by the kidneys.<\/jats:p>","DOI":"10.1530\/acta.0.0970454","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"454-460","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["Serum 3'-monoiodothyronine levels in normal subjects and in patients with thyroid and non-thyroid disease"],"prefix":"10.1093","volume":"97","author":[{"given":"C.","family":"Kirkegaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Faber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"K\u00f8lendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Francis","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. B.","family":"Lumholtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Siersb\u00e6k-Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th.","family":"Friis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/97\/4\/acta_97_4_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/97\/4\/acta_97_4_005.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:11:25Z","timestamp":1676391085000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/97\/4\/454\/6804083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0970454","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,8]]}}}