{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:16:15Z","timestamp":1790810175921,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>The effects of oestradiol (Oe<jats:sub>2<\/jats:sub>), oestrone (Oe<jats:sub>1<\/jats:sub>), oestriol (Oe<jats:sub>3<\/jats:sub>), oestetrol (Oe<jats:sub>4<\/jats:sub>) on the induction of the progesterone receptor (PgR) and growth of MCF-7 cells are compared. All the four oestrogens increase cell PgR concentration. Analysis of the dose-response curves shows induction by Oe<jats:sub>2<\/jats:sub> to be 10 times and 50 times greater than Oe<jats:sub>3<\/jats:sub> and Oe<jats:sub>4<\/jats:sub>, respectively. Oe<jats:sub>1<\/jats:sub> and Oe<jats:sub>2<\/jats:sub> are equally effective, even with consideration of metabolic conversion of Oe<jats:sub>1<\/jats:sub> into Oe<jats:sub>2<\/jats:sub>. When compared with untreated cells, Oe<jats:sub>2<\/jats:sub>, Oe<jats:sub>3<\/jats:sub> and Oe<jats:sub>4<\/jats:sub> do not influence significantly the plating efficiency but all 3 hormones increase thymidine incorporation of cells in log phase growth. Oe<jats:sub>2<\/jats:sub>, Oe<jats:sub>3<\/jats:sub> and Oe<jats:sub>4<\/jats:sub> are able to rescue the growth inhibition induced by antioestrogens. The respective potency compared to Oe<jats:sub>2<\/jats:sub> is again in the range of 10 and 50 times lower for Oe<jats:sub>3<\/jats:sub> and Oe<jats:sub>4<\/jats:sub>, respectively. On the other hand Oe<jats:sub>1<\/jats:sub> decreases plating efficiency, thymidine incorporation and does not rescue the growth inhibition induced by antioestrogens when the metabolic conversion of Oe<jats:sub>1<\/jats:sub> into Oe<jats:sub>2<\/jats:sub> is prevented. Thus, Oe<jats:sub>3<\/jats:sub> and Oe<jats:sub>4<\/jats:sub> behave like complete Oe<jats:sub>2<\/jats:sub> agonists whereas Oe<jats:sub>1<\/jats:sub> has dissociated effects, agonist on PgR induction and antagonist on cell growth.<\/jats:p>","DOI":"10.1530\/acta.0.0980073","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":20,"title":["Different effects of oestradiol, oestriol, oestetrol and of oestrone on human breast cancer cells (MCF-7) in long term tissue culture"],"prefix":"10.1093","volume":"98","author":[{"given":"S.","family":"Jozan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kreitmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bayard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/98\/1\/acta_98_1_012.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/98\/1\/acta_98_1_012.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:11:43Z","timestamp":1676391103000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/98\/1\/73\/6803960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0980073","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,9]]}}}