{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T22:52:07Z","timestamp":1697583127086},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,3]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>The effects of oestrogens on the release of thyroxine iodide (T<jats:sub>4<\/jats:sub> I) and non-T<jats:sub>4<\/jats:sub> I by the thyroid gland of 6 normal subjects and 3 thyrotrophin (TSH)-treated patients with hypopituitarism were assessed before, during and after treatment with 25 mg of Dienoestrol (Glaxo Lab.), orally, daily, during 8 days. Each subject received an iv injection of 150 \u03bcCi of <jats:sup>125<\/jats:sup>I followed 6 days later by an iv injection of 75 \u03bcCi of [<jats:sup>131<\/jats:sup>I]T<jats:sub>4<\/jats:sub>. Blood samples and collections of urine were obtained every 12 h. From plasma and urinary (U) radioactivity, the ratio U[<jats:sup>125<\/jats:sup>I]\/ U[<jats:sup>131<\/jats:sup>I], U[<jats:sup>125<\/jats:sup>I]\/PB[<jats:sup>125<\/jats:sup>I] and U[<jats:sup>131<\/jats:sup>I]\/PB[<jats:sup>131<\/jats:sup>I] were obtained and served to calculate thyroidal iodine release and non-T<jats:sub>4<\/jats:sub> I secretion by the thyroid gland. T<jats:sub>4<\/jats:sub> I secretion was equivalent to T<jats:sub>4<\/jats:sub> I disposal rate obtained by the semilogarithmic regression line of PB[<jats:sup>131<\/jats:sup>I]. In normal subjects, oestrogens decreased T<jats:sub>4<\/jats:sub> I secretion from 491 \u00b1 57 (<jats:sc>sd<\/jats:sc>) nmol\/day to 451 \u00b1 60 nmol (<jats:italic>P<\/jats:italic> &lt; 0.025), while in the same subjects serum TSH increased with oestrogens from 3.3 \u00b1 1.1 to 6.6 \u00b1 2.1 mU\/l (<jats:italic>P<\/jats:italic> &lt; 0.01). The non-T<jats:sub>4<\/jats:sub> I secretion had a mean of 585 \u00b1 307 nmol\/day during control, 324 \u00b1 199 nmol during oestrogens (<jats:italic>P<\/jats:italic> &lt; 0.01) and 480 \u00b1 286 nmol after oestrogens (<jats:italic>P<\/jats:italic> &lt; 0.05 vs oestrogens). In the TSH-treated patients oestrogens induced non-significant reductions in T<jats:sub>4<\/jats:sub> I and non-T<jats:sub>4<\/jats:sub> I secretion, although total iodine secretion decreased significantly (<jats:italic>P<\/jats:italic> &lt; 0.05). The data is consonant with a partial inhibition by oestrogens of thyroid gland release.<\/jats:p>","DOI":"10.1530\/acta.0.0990386","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"386-392","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":4,"title":["Inhibition of thyroidal iodine release by oestrogens in euthyroid subjects"],"prefix":"10.1093","volume":"99","author":[{"given":"Angel A.","family":"Zaninovich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n","family":"Boado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgardo","family":"Ulloa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niall R.","family":"Bromage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Matty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/99\/3\/acta_99_3_011.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/99\/3\/acta_99_3_011.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:12:53Z","timestamp":1676391173000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/99\/3\/386\/6803800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0990386","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,3]]}}}