{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:44:47Z","timestamp":1757540687968},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,6]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>A comparison was made of the efficacy of intravenously (iv) and intraventricularly administered synthetic Gn-RH in inducing ovulation in conscious and urethane anaesthetized rabbits. Via the iv route of administration, the minimum dose of Gn-RH required to induce ovulation in all animals of the conscious group was 300 ng\/kg body weight. This is in contrast to the larger systemic dose (400 ng\/kg body weight) of Gn-RH required to achieve the same results in urethane anaesthetized but otherwise identically treated rabbits. This suggests that although ovulation is not blocked by an anaesthetic dose of urethane (1.25 g\/kg), the ovulatory response is altered in some way by the anaesthetic. When administered intraventricularly, the minimum dose of Gn-RH required to induce ovulation in anaesthetized animals was only 100 ng\/kg body weight or 25% of the equivalent systemic dose. Systemically ineffective doses of Gn-RH (\u2264 200 ng\/kg body weight) also induced ovulation in the anaesthetized group when administered via the third cerebral ventricle.<\/jats:p>\n<jats:p>All animals that ovulated did so between 13 and 16 h following Gn-RH administration and the number of ova recovered paralleled the number of ruptered follicles. A graded increase in the number of ova released with dosage of Gn-RH was not observed.<\/jats:p>\n<jats:p>In this study, the smaller effective dose requirement for intraventricularly administered decapeptide supports the view that Gn-RH in the CSF circumvents the general circulation and reaches the portal vasculature directly via the median eminence.<\/jats:p>","DOI":"10.1530\/acta.0.1000285","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"285-289","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["Ovulation in the rabbit following intraventricular and intravenous administration of synthetic Gn-RH"],"prefix":"10.1093","volume":"100","author":[{"given":"J. E.","family":"Bruni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"Montemurro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Clattenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/100\/2\/acta_100_2_021.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/100\/2\/acta_100_2_021.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:13:37Z","timestamp":1676391217000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/100\/2\/285\/6802973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,6]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1000285","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,6]]}}}