{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:48:28Z","timestamp":1761518908929},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,7]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>Spontaneous development of hyperprolactinaemia was investigated by measuring prolactin levels in 34 hyperprolactinaemic females with a normal sella turcica, in 19 females with a radiologically proven prolactinoma, and in 19 females with a histologically proven prolactinoma after transsphenoidal surgery. Prolactin levels remained unchanged or declined in 69 patients followed over a period of up to 6 years. In one patient with a normal sella turcica, prolactin levels increased accompanied by the development of a radiologically detectable microprolactinoma. In one patient with a radiologically proven macroprolactinoma the increase of human prolactin (hPrl) levels was accompanied by infiltrative and parasellar prolactinoma growth. One patient showed a dramatic increase of post-operative persisting elevated hPrl levels without radiological changes. These findings suggest that prolactinomas in general have a limited growth potential which should be considered in the management of hyperprolactinaemic patients.<\/jats:p>","DOI":"10.1530\/acta.0.1000333","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"333-336","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":22,"title":["Spontaneous development of hyperprolactinaemia"],"prefix":"10.1093","volume":"100","author":[{"given":"Hanns-Kristian","family":"Rjosk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Fahlbusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus von","family":"Werder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/100\/3\/acta_100_3_003.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/100\/3\/acta_100_3_003.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:13:40Z","timestamp":1676391220000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/100\/3\/333\/6803071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1000333","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,7]]}}}