{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:42Z","timestamp":1676438622609},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,8]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>Experiments were designed to study the effect of exogenous somatostatin (S) on basal levels or parathyroid hormone (PTH) and on PTH responses to isoproterenol (ISO), adrenaline (A) or ethyleneglycol-bis (\u03b2-aminoethylether) N,N'-tetraacetate (EGTA) in cattle. During S infusions (6.11 nmol injected iv as a bolus and 0.82 nmol\/kg\/min infused iv for 30 or 60 min) plasma levels of PTH and calcium (Ca) did not change, whereas concentrations of immunoreactive insulin (IRI) decreased significantly (<jats:italic>P<\/jats:italic> &lt; 0.01). In response to ISO (0.09 nmol\/kg\/min) or EGTA (5.6 \u03bcmol\/kg\/min, depressing plasma Ca by 0.27 nmol\/l) PTH levels were similarly increased (<jats:italic>P<\/jats:italic> &lt; 0.05) both in the absence and presence of S. On the other hand, S supressed IRI responses to ISO. During 60-min infusions of EGTA (3.15 \u03bcmol\/kg\/min) plasma Ca fell to significantly lower levels (<jats:italic>P<\/jats:italic> &lt; 0.01) during simultaneous infusions of S than in the absence of exogenous S, while the magnitude of PTH responses was similar. The results do not support a role of somatostatin on basal PTH levels and on PTH responses to \u03b2-adrenergic agonists or hypocalcaemia under conditions, in which S markedly lowers IRI levels and IRI responses to ISO. However, S apparently reduces Ca mobilisation during abrupt hypocalcaemia.<\/jats:p>","DOI":"10.1530\/acta.0.1000534","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"534-538","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["Effects of somatostatin on parathyroid hormone levels and on responses of parathyroid hormone to \u03b2-adrenergic agonists and hypocalcaemia"],"prefix":"10.1093","volume":"100","author":[{"given":"J. W.","family":"Blum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/100\/4\/acta_100_4_009.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/100\/4\/acta_100_4_009.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:13:52Z","timestamp":1676391232000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/100\/4\/534\/6802816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1000534","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8]]}}}