{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:59Z","timestamp":1676438639134},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,10]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n<jats:p>The effect of iv calcium on the urinary excretion of total adenosine-3',5',-monophosphate (cAMP) and total hydroxyproline (OH-P) was investigated in 5 children with parathyroid hormone (PTH)-deficient and PTH-resistant hypoparathyroidism, two of them being normocalcaemic during the study, in comparison to 4 healthy and 8 epileptic children and adolescents. Eighteen mg\/kg body weight calcium, infused over 3 h, induced a decrease of cAMP to (mean \u00b1 <jats:sc>sd<\/jats:sc>) 82.1 \u00b1 2.5% of the baseline value in controls and to 69.8 \u00b1 9.7% in epileptic patients with an inverse correlation to the relative increase of serum calcium after the infusion in both groups (r = \u22120.75, <jats:italic>P<\/jats:italic> &lt; 0.01). In contrast, the cAMP excretion <jats:italic>increased<\/jats:italic> after calcium load in the 5 hypoparathyroid children to 118.7 \u00b1 14.9% of baseline despite a comparable serum calcium increase. OH-P decreased to (mean \u00b1 <jats:sc>SD<\/jats:sc>) 48.0 \u00b1 6.8% of baseline in controls, 48.2 \u00b1 12.7% in the epileptic patients and 39.4 \u00b1 9.8% in the children with hypoparathyroidism, the differences between the three groups being statistically not significant.<\/jats:p>\n<jats:p>It is concluded that the simple measurement of urinary cAMP before and after calcium infusion may provide a diagnostic tool to identify hypoparathyroid patients even in the normocalcaemic state. In contrast, the measurement of the calcium-induced suppressibility of OH-P does not discriminate these patients from subjects with normal parathyroid function.<\/jats:p>","DOI":"10.1530\/acta.0.1010217","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:36:12Z","timestamp":1229376972000},"page":"217-222","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":0,"title":["Effect of intravenous calcium on urinary cyclic adenosine-3',5'-monophosphate and hydroxyproline in children with hypoparathyroidism"],"prefix":"10.1093","volume":"101","author":[{"given":"Klaus","family":"Kruse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Kracht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/101\/2\/acta_101_2_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/101\/2\/acta_101_2_010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:14:15Z","timestamp":1676391255000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/101\/2\/217\/6802474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,10]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1010217","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,10]]}}}