{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:51:28Z","timestamp":1757310688333},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,4]]},"abstract":"<jats:title>Abstract<jats:sup>1<\/jats:sup><\/jats:title>\n<jats:p>A 24 years old male with pseudohermaphroditism due to a deficiency in 17-ketosteroid reductase activity is described. Plasma \u0394<jats:sub>4<\/jats:sub> is 21 times higher than normal for an adult male, \u0394<jats:sub>4<\/jats:sub>\/T is greater than 6, both E<jats:sub>1<\/jats:sub> and E<jats:sub>2<\/jats:sub> are elevated and E<jats:sub>1<\/jats:sub>\/E<jats:sub>2<\/jats:sub> = 3.<\/jats:p>\n<jats:p>There is very slight modification of \u0394<jats:sub>4<\/jats:sub> on administration of ACTH, dexamethasone, hCG and fluoxymesterone. Steroid concentrations in the spermatic veins and arteries confirm the testicular origin of the increased secretion of \u0394<jats:sub>4<\/jats:sub> and E<jats:sub>1<\/jats:sub> and show a lower secretion by the cryptorchidic testis.<\/jats:p>\n<jats:p>In vitro testicular tissue incubation and fibroblast studies confirm the 17-ketosteroid reductase deficiency and rule out any other anomaly as the cause of the ambiguous genitalia.<\/jats:p>\n<jats:p>Psychologically the patient seemed to be identified with a female social and sexual role in spite of her advanced degree of virilization.<\/jats:p>","DOI":"10.1530\/acta.0.1020633","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"633-640","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":10,"title":["17-ketosteroid reductase deficiency in an adult patient without gynaecomastia but with female psychosexual orientation"],"prefix":"10.1093","volume":"102","author":[{"given":"M.","family":"Mill\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Aud\u00ed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Martinez-Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J. Martinez","family":"de Osaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Viguera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Esmatjes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Peig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Vilardell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/102\/4\/acta_102_4_027.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/102\/4\/acta_102_4_027.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:35Z","timestamp":1676391335000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/102\/4\/633\/6802574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1020633","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,4]]}}}