{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:52:00Z","timestamp":1773661920019,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:p>Abstract. The regulatory function of glucocorticoids on thyroid hormone concentrations was studied in patients with adrenocortical insufficiency (ACI, n = 8) and in healthy subjects (n = 6). In patients with ACI withdrawal of glucocorticoid substitution for 84 h led to an increase in serum concentrations of total triiodothyronine (TT<jats:sub>3<\/jats:sub>) from 110 \u00b1 20 to 133 \u00b1 22 ng\/dl and a decrease of serum reverse-T<jats:sub>3<\/jats:sub> (rT<jats:sub>3<\/jats:sub>) from 23 \u00b1 6 to 18 \u00b1 6 ng\/dl, whereas subsequent administration of dexamethasone (0.5 mg po q.i.d. for 3 days) induced a fall in TT<jats:sub>3<\/jats:sub> (129 \u00b1 22 to 88 \u00b1 16 ng\/dl) and a rise in rT<jats:sub>3<\/jats:sub> (17 \u00b1 5 to 37 \u00b1 11 ng\/dl) concentrations. Serum levels of total thyroxine (TT<jats:sub>4<\/jats:sub>) were unchanged by either withdrawal or re-administration of glucocorticoids. Basal plasma thyrotrophin (TSH) concentrations were unchanged by glucocorticoid withdrawal and fell from 2.2 \u00b1 1.5 to 1.1 \u00b1 0.8 mU\/l during subsequent dexamethasone therapy.<\/jats:p>\n        <jats:p>In healthy subjects a decrease of TT<jats:sub>3<\/jats:sub> (89 \u00b1 8 to 69 \u00b1 8 ng\/dl) and an increase in rT<jats:sub>3<\/jats:sub> (19 \u00b1 5 to 32 \u00b1 8 ng\/dl) concentrations were seen after stimulation of endogenous cortisol production by prolonged infusion of ACTH<jats:sup>1-24<\/jats:sup> (0.5 mg, t = 8 h on 2 consecutive days), whereas concentrations of TT<jats:sub>4<\/jats:sub> remained unchanged. During subsequent administration of dexamethasone serum level of both, TT<jats:sub>3<\/jats:sub> and rT<jats:sub>3<\/jats:sub> returned to basal levels. Thus, changes in thyroid hormone concentrations are induced by alterations of substitution therapy in patients with ACI. In healthy subjects the application of 2 mg dexamethasone\/day following prolonged maximal stimulation of endogenous cortisol by iv ACTH may represent a state of relative glucocorticoid deficiency, thus explaining the observed hormonal changes, which are inverse to those generally induced in healthy man by endogenous or exogenous glucocorticoids.<\/jats:p>","DOI":"10.1530\/acta.0.1030254","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"254-258","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":8,"title":["Thyroid function in adrenocortical insufficiency during withdrawal and re-administration of glucocorticoid substitution"],"prefix":"10.1093","volume":"103","author":[{"given":"B.","family":"Grubeck-Loebenstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Vierhapper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Waldh\u00e4usl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Nowotny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/103\/2\/acta_103_2_020.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/103\/2\/acta_103_2_020.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:15:54Z","timestamp":1676391354000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/103\/2\/254\/6795633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1030254","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6]]}}}