{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:39Z","timestamp":1760189019924},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:p>Abstract. The mechanism of thyroid action on bone was studied in 15 patients with thyrotoxicosis and 14 patients with hypothyroidism. The patients were studied twice: when they were thyrotoxic or hypothyroid and when they had returned to a euthyroid state. Parameters of bone turnover showed a decrease when hyperthyroid patients became euthyroid: serum calcium (2.51 \u00b1 0.04 vs 2.38 \u00b1 0.03 mmol\/l, <jats:italic>P<\/jats:italic>&lt; 0.05), acid phosphatase (11.7 \u00b1 0.7 vs 8.3 \u00b1 0.4 U\/l, <jats:italic>P<\/jats:italic> &lt; 0.01), alkaline phosphatase (124 \u00b1 11 vs 98 \u00b1 8 U\/l, <jats:italic>P<\/jats:italic> &lt;0.05), the calcium\/creatinine ratio (1.03 \u00b1 0.31 vs 0.43 \u00b1 0.07, <jats:italic>P<\/jats:italic> &lt;0.01) and the hydroxyproline\/creatinine ratio in the urine (69.9 \u00b1 12 vs 20.7 \u00b1 2.4, <jats:italic>P<\/jats:italic> &lt; 0.01). These parameters showed an increase when hypothyroid patients became euthyroid: serum calcium (2.36 \u00b1 0.03 vs 2.48 \u00b1 0.04 mmol\/l, <jats:italic>P<\/jats:italic> &lt; 0.01), alkaline phosphatase (60 \u00b1 4 vs 84 \u00b1 8 U\/l, <jats:italic>P<\/jats:italic> &lt; 0.05) and the hydroxyproline\/creatinine ratio in the urine (15.9 \u00b1 4.3 vs 25.3 \u00b1 3.2, <jats:italic>P<\/jats:italic> &lt; 0.05). Changes in the calcium regulating hormones, parathyroid hormone, calcitonin and vitamin <jats:sc>d<\/jats:sc> metabolites, were not observed when hyperthyroid patients became euthyroid. When hypothyroid patients were treated a decrease in serum levels of 1.25-dihydroxyvitamin <jats:sc>d<\/jats:sc> (32.6 \u00b1 4.6 vs 17.9 \u00b1 2.5 ng\/l, <jats:italic>P<\/jats:italic> &lt;0.01) was observed. Serum growth hormone levels decreased when hypothyroid patients became euthyroid (4.3 \u00b1 0.5 vs 2.6 \u00b1 0.4 mU\/l, <jats:italic>P<\/jats:italic> &lt; 0.01). The possible mechanisms of thyroid action on bone are discussed. The presented findings are in accordance with a direct effect of thyroid hormones on bone in thyrotoxicosis. An additional factor could be somatomedin, that might also be involved in changes in bone turnover in hyper- and hypothyroidism.<\/jats:p>","DOI":"10.1530\/acta.0.1040042","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"42-49","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":19,"title":["Thyroid function and bone turnover"],"prefix":"10.1093","volume":"104","author":[{"given":"J. W.J.","family":"Bijlsma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Duursma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M. M.","family":"Roelofs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"der Kinderen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/104\/1\/acta_104_1_008.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/104\/1\/acta_104_1_008.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:35Z","timestamp":1676391395000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/104\/1\/42\/6795674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,9]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1040042","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,9]]}}}