{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:26Z","timestamp":1676438606291},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,11]]},"abstract":"<jats:p>Abstract. Rats receiving large doses of thyroxine (30 \u03bcg\/5 doses) during their first days of life develop an apparently permanent alteration of the hypothalamus-pituitary-thyroid complex. This neonatal thyrotoxicosis has been called neo-T<jats:sub>4<\/jats:sub> syndrome. A state of permanent but not very severe hypothyroidism seems to be induced, accompanied by a decrease in pituitary GH content at least until day 22. In this work, growth hormone content has been measured by a specific radioimmunoassay in the anterior pituitary of 45 and 78 day old neo-T<jats:sub>4<\/jats:sub> and control (saline-injected) rats. GH content of the adult neo-T<jats:sub>4<\/jats:sub> treated animals was significantly lower than that of the adult controls. Administration of different doses of T<jats:sub>4<\/jats:sub> (1.7 \u03bcg\/100 g body weight\/3 doses or 2.5 \u03bcg\/100 g body weight\/8 doses, to 70 day old rats, and 5 \u03bcg\/100 g body weight\/3 doses to 42 day old rats) to adult neo-T<jats:sub>4<\/jats:sub> rats did not alter these decreased pituitary GH levels. This differs from hypothyroid rats, in which T<jats:sub>4<\/jats:sub> administration has been shown to increase pituitary GH content. A third approach was to thyroidectomize neo-T<jats:sub>4<\/jats:sub> and control rats and administer 5 \u03bcg T<jats:sub>4<\/jats:sub>\/100 g body weight, which produced the same increase in pituitary GH in both groups of animals. These results seem to indicate that changes in pituitary GH content of neo-T<jats:sub>4<\/jats:sub> rats are not due to hypothyroidism. Thus, it would appear that treatment with large T<jats:sub>4<\/jats:sub> doses during the early perinatal period not only deranges the hypothalamic-pituitary-thyroid axis but other pituitary functions as well.<\/jats:p>","DOI":"10.1530\/acta.0.1040340","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"340-344","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["Effects of l-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis"],"prefix":"10.1093","volume":"104","author":[{"given":"A. M.","family":"Pascual-Leone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Besa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Herv\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Escriv\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/104\/3\/acta_104_3_014.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/104\/3\/acta_104_3_014.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:16:54Z","timestamp":1676391414000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/104\/3\/340\/6795715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,11]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1040340","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,11]]}}}