{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:01:31Z","timestamp":1767855691466,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:p>Abstract. Adult ovariectomized rats were treated for 14 days with oestradiol benzoate (E<jats:sub>2<\/jats:sub>B) 15 \u03bcg\/kg\/d and oestradiol benzoate 15 \u03bcg\/kg\/d + progesterone (PRO) 15 mg\/kg\/d for induction of mammary gland parenchymal stimulation.<\/jats:p>\n        <jats:p>Histological examination and whole mount preparation demonstrated that ductal growth in the mammary gland after E<jats:sub>2<\/jats:sub>B treatment was completely antagonized by tamoxifen (TAM) 0.5 mg\/kg\/d. Parallel DNA concentrations in the mammary gland were decreased to control levels by TAM 0.5, 5 and 15 mg\/kg\/d.<\/jats:p>\n        <jats:p>E<jats:sub>2<\/jats:sub>B-induced hyperprolactinaemia in the forenoon (basal secretion was equally reduced by TAM 0.5, 5 and 15 mg\/kg\/d). In the afternoon, when prolactin (Prl) secretion is at its maximum, TAM 0.5 mg\/kg\/d turned out to be ineffective to abolish Prl surge, but TAM 5 and 15 mg\/kg\/d reduced serum Prl concentrations in a doserelated manner.<\/jats:p>\n        <jats:p>Immunoperoxidase staining of Prl cells in the pars distalis of the hypophysis indicated that adaptive hypertrophy and signs of hypersecretion after E<jats:sub>2<\/jats:sub>B were abolished by TAM 5 mg\/kg\/d. Luteotrophic cells clearly showed cellular atrophy, regression and secretory inactivity.<\/jats:p>\n        <jats:p>Maximal tubulo-alveolar mammary parenchymal stimulation in rats treated with E<jats:sub>2<\/jats:sub>B-PRO was slightly inhibited by TAM 0.5 mg\/kg\/d. Histology showed a small disseminated parenchymal islet. DNA concentrations only were partially decreased by the anti-oestrogen though serum Prl concentrations were found to be completely decreased to control levels. Secretory activity of Prl cells was reduced by TAM 0.5 mg\/kg\/d.<\/jats:p>\n        <jats:p>In E<jats:sub>2<\/jats:sub>B-PRO treated rats lisuride had poor inhibitory activity on Prl levels and none on DNA concentrations in the mammary gland.<\/jats:p>\n        <jats:p>Combined treatment with TAM and lisuride significantly decreased DNA concentration in the mammary gland compared to animals which received E<jats:sub>2<\/jats:sub>B-PRO. Also Prl levels were at a minimum. Histology performed on the mammary gland showed only slight tubulo- but no tubulo-alveolar activation. Luteotrophic cells in the pituitary gland stained by the immunoperoxidase technique appeared regressive, shrunken and atrophied.<\/jats:p>","DOI":"10.1530\/acta.0.1050360","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"360-370","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":9,"title":["Anti-oestrogenic effects of tamoxifen on mammary gland and hypophysis in female rats"],"prefix":"10.1093","volume":"105","author":[{"given":"Stephan","family":"G\u00f6tze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukishige","family":"Nishino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedmund","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/105\/3\/acta_105_3_012.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/105\/3\/acta_105_3_012.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:17:54Z","timestamp":1676391474000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/105\/3\/360\/6798695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1050360","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}