{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:19:38Z","timestamp":1761016778435},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:p>Abstract. To evaluate the effect of anticonvulsants on serum levels of free thyroxine (FT<jats:sub>4<\/jats:sub>) and thyroxinebinding globulin (TBG), 32 patients with epilepsy receiving long-term anticonvulsant treatment (mean duration 81.8 \u00b1 8.9 months) were employed in the present study. The serum levels of total thyroxine (TT<jats:sub>4<\/jats:sub>), total triiodothyronine (TT<jats:sub>3<\/jats:sub>), T<jats:sub>3<\/jats:sub> resin uptake (T<jats:sub>3<\/jats:sub>U) and thyrotrophin (TSH) were also measured. Free thyroxine index (FT<jats:sub>4<\/jats:sub>I) was calculated from TT<jats:sub>4<\/jats:sub> and T<jats:sub>3<\/jats:sub>U. Mean levels of these thyroid function tests were as follows: 5.52 \u00b1 1.51 \u03bcg\/dl (TT<jats:sub>4<\/jats:sub>), 1.16 \u00b1 0.32 ng\/dl (FT<jats:sub>4<\/jats:sub>), 101.5 \u00b1 16.2 ng\/dl (TT<jats:sub>3<\/jats:sub>), 27.5 \u00b1 2.6% (T<jats:sub>3<\/jats:sub>U), 19.64 \u00b1 3.97 \u03bcg\/ml (TBG), 1.50 \u00b1 0.36 (FT<jats:sub>4<\/jats:sub>I) and 2.21 \u00b1 0.18 \u03bcU\/ml (TSH). These values except for T<jats:sub>3<\/jats:sub>U and TSH were significantly lower than normal values (<jats:italic>P<\/jats:italic> &lt; 0.01). Using correlation analysis, a significant dose-dependency (daily doses) was found between diphenylhydantoin (DPH) and TT<jats:sub>4<\/jats:sub>, FT<jats:sub>4<\/jats:sub> and TBG. Other anticonvulsants (bartiturates, carbamazepine, primidone) or duration of treatment were not significantly correlated with thyroid function tests. Therefore serum levels of DPH were also measured in 19 out of 32 patients receiving anticonvulsant treatment. Significant negative correlation was found between serum levels of DPH and FT<jats:sub>4<\/jats:sub> (r = \u22120.65) and DPH and TBG (r = \u22120.61).<\/jats:p>","DOI":"10.1530\/acta.0.1050477","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"477-481","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["Lowering effect of diphenylhydantoin on serum free thyroxine and thyroxine binding globulin (TBG)"],"prefix":"10.1093","volume":"105","author":[{"given":"Hitoshi","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Hiraiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matsuei","family":"Miyasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/105\/4\/acta_105_4_008.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/105\/4\/acta_105_4_008.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:18:02Z","timestamp":1676391482000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/105\/4\/477\/6798757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1050477","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4]]}}}