{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:21Z","timestamp":1676438601659},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:p>Abstract. Thyrotrophin-releasing hormone (TRH), like several other neuropeptides, has been detected in the gastro-intestinal tract of adult rats. More recently, elevated concentrations of TRH have been found in the neonatal rat pancreas. This study was undertaken to evaluate pancreatic TRH degrading activity (TRH-DA) in infant rats from birth until adult life. Pancreatic TRH of age-matched rats was also measured by radioimmunoassay.<\/jats:p>\n        <jats:p>TRH-DA was present in normal adult rat pancreas; though absent at birth and in the early postnatal period up to day 7, this activity was detected during the remainder of the developmental period. TRH content (pg \u00b1 <jats:sc>sem<\/jats:sc> per pancreas) was 1139 \u00b1 88 on day 1, reached a peak value of 7360 \u00b1 758 at day 2 and then decreased steadily to adult level.<\/jats:p>\n        <jats:p>TRH-DA has been found to be present at birth in hypothalamus and liver but not in plasma. The developmental patterns of TRH-DA in plasma and in pancreas were parallel and seem to be thyroid hormone dependent. The absence of TRH-DA in the neonatal pancreas may also be related to the high TRH concentrations detected in this organ during the neonatal period.<\/jats:p>","DOI":"10.1530\/acta.0.1060102","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"102-108","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":21,"title":["Developmental pattern of TRH-degrading activity and TRH content in rat pancreas"],"prefix":"10.1093","volume":"106","author":[{"given":"Sonia","family":"Aratan-Spire","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Czernichow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/106\/1\/acta_106_1_017.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/106\/1\/acta_106_1_017.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:18:14Z","timestamp":1676391494000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/106\/1\/102\/6801614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1060102","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5]]}}}