{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:37Z","timestamp":1676438617436},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,7]]},"abstract":"<jats:p>Abstract. To investigate the respective role of triiodothyronine (T<jats:sub>3<\/jats:sub>) and thyroxine (T<jats:sub>4<\/jats:sub>) in the regulation of TSH secretion, we studied the action of sodium ipodate and propylthiouracil (PTU) in 11 athyreotic patients. The <jats:sc>l<\/jats:sc>T<jats:sub>4<\/jats:sub> replacement dose was adjusted to obtain, in each patient, a normal basal TSH level and a normal TSH response to TRH. In the 5 ipodate-treated patients (single 6 g oral dose), the mean serum T<jats:sub>3<\/jats:sub> level fell by 64% below the baseline value and serum rT<jats:sub>3<\/jats:sub> rose 180% above the baseline. The free T<jats:sub>4<\/jats:sub> index (FT<jats:sub>4<\/jats:sub>I) did not change whereas the mean serum TSH concentration increased 280% above baseline values. In the 6 PTU-treated patients (250 mg orally every 6 h for 10 days), serum T<jats:sub>3<\/jats:sub> levels fell 33%, serum rT<jats:sub>3<\/jats:sub> increased up to 82% and the FT<jats:sub>4<\/jats:sub>I did not change. The mean serum TSH concentration increased 68% above the baseline value. Thus, the mean percentage increase in serum TSH was less in PTU- than in ipodate-treated patients (68% vs 280%). Statistical analysis of the correlation between the serum T<jats:sub>3<\/jats:sub> decrease (\u0394T<jats:sub>3<\/jats:sub>) and the serum TSH (\u0394TSH) increase demonstrated that for the same T<jats:sub>3<\/jats:sub> diminution, the ipodate-treated group displayed higher increase of TSH than the PTU-treated patients. In the rat, PTU interferes with the 5'-deiodination of T<jats:sub>4<\/jats:sub> in the liver and kidney but not in the pituitary, while ipodate appears to have the same effect in all tissues. If this holds true for human subjects, our data strongly suggest that circulating T<jats:sub>4<\/jats:sub> (through its intrapituitary conversion to T<jats:sub>3<\/jats:sub>) shares with serum T<jats:sub>3<\/jats:sub> the capacity to regulate TSH secretion in man.<\/jats:p>","DOI":"10.1530\/acta.0.1060338","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"338-345","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":2,"title":["Effects of sodium ipodate and propylthiouracil in athyreotic human subjects, role of triiodothyronine and pituitary thyroxine monodeiodination in thyrotrophin regulation"],"prefix":"10.1093","volume":"106","author":[{"given":"G.","family":"Schaison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Thomopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Leguillouzic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Moatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/106\/3\/acta_106_3_008.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/106\/3\/acta_106_3_008.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:18:27Z","timestamp":1676391507000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/106\/3\/338\/6801838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1060338","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,7]]}}}