{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:20:06Z","timestamp":1760368806710},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,10]]},"abstract":"<jats:p>Abstract. Some endocrinological effects of single daily oral administration of 150 mg ketoconazole for 15 days were investigated in 4 male beagle dogs. Plasma testosterone fell markedly within 3\u20134 h and then progressively returned to control concentrations by 10 h after drug administration. On the other hand, plasma 17\u03b1-hydroxyprogesterone, progesterone and 17\u03b1,20\u03b1-dihydroxyprogesterone increased within 3\u201310 h before returning to basal values after 24 h.<\/jats:p>\n        <jats:p>Plasma LH did not rise significantly though some high individual levels were noted. Plasma cortisol and oestradiol-17\u03b1 levels were not significantly modified by the treatment.<\/jats:p>\n        <jats:p>These results confirm that a high therapeutic dose of ketoconazole, given orally once a day, transiently inhibits in vivo the 17\u201320 lyase enzyme of the testis, without modifying basal cortisol and oestradiol-17\u03b2 plasma concentrations and that enzymatic inhibition still occurs after daily treatment for up to 2 weeks but remains transient and parallels the resorption profile of the drug so that normal plasma testosterone levels are observed from 10 to 24 h after drug intake. However, permanent inhibition of androgen biosynthesis might be obtained by the administration of high doses of ketoconazole given several times a day.<\/jats:p>","DOI":"10.1530\/acta.0.1070275","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"275-281","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":20,"title":["Endocrinological effects of single daily ketoconazole administration in male beagle dogs"],"prefix":"10.1093","volume":"107","author":[{"given":"Roland","family":"De Coster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominiek","family":"Beerens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jef","family":"Dom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustaaf","family":"Willemsens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/107\/2\/acta_107_2_022.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/107\/2\/acta_107_2_022.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:18:51Z","timestamp":1676391531000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/107\/2\/275\/6801580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,10]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1070275","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,10]]}}}