{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:22:55Z","timestamp":1676438575638},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:p>Abstract. In order to evaluate the effect of hyperprolactinaemia on gonadal function in men, testicular stimulation by human chorionic gonadotrophin (hCG) (5000 IU\/day, 3 consecutive days) was performed on 6 men with chronic hyperprolactinaemia and 6 control subjects. The following parameters were measured before and during the 4 consecutive days following the injections of hCG: the concentration in plasma of testosterone (T), oestradiol-17\u03b2 (E<jats:sub>2<\/jats:sub>), dihydrotestosterone (DHT) and the urinary excretion of testosterone glucuronide (TG) and 5\u03b1-androstane-3\u03b1,17\u03b2-diol glucuronide (3\u03b1-DiolG). The rises in T, E<jats:sub>2<\/jats:sub>, DHT and the ratios of T\/DHT and TG\/3\u03b1-Diol G were similar in both groups, but the rises in TG and 3\u03b1-Diol G were lower in the hyperprolactinaemic group after hCG. There was no correlation between the response of T and the increment of E<jats:sub>2<\/jats:sub> in either group. It is suggested that in men with chronic hyperprolactinaemia: 1) there is diminished testicular response to hCG; this could be due to chronic gonadotrophin deficiency or to a direct effect of hyperprolactinaemia on the testes, 2) there is no modulation of T synthesis through inhibition of aromatase activity and E<jats:sub>2<\/jats:sub> secretion and 3) the 5\u03b1-reduction of T is not deficient.<\/jats:p>","DOI":"10.1530\/acta.0.1080565","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"565-569","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":4,"title":["Testicular response to human chorionic gonadotrophin in chronic hyperprolactinaemia"],"prefix":"10.1093","volume":"108","author":[{"given":"H. M.","family":"Heshmati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Turpin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nahoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Carayon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gueguen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"de Gennes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/108\/4\/acta_108_4_022.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/108\/4\/acta_108_4_022.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:21:06Z","timestamp":1676391666000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/108\/4\/565\/6801875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1080565","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,4]]}}}