{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:24Z","timestamp":1676438604219},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:p>Abstract. Because the concentrations of serum free thyroxine (FT<jats:sub>4<\/jats:sub>) and thyroid hormone binding globulin (TBG) have not been fully evaluated in preterm infants at the immediate post-natal period, we studied the longitudinal changes of serum FT<jats:sub>4<\/jats:sub> and TBG, along with thyroxine (T<jats:sub>4<\/jats:sub>) and thyroid stimulating hormone (TSH), at birth (cord blood), 2 days, 1 week and 2 weeks of age in 7 infants with birth body weight \u2266 1000 g, 7 infants with body weight 1001 to 1350 g, 11 infants with body weight 1351 to 2499 g, and 11 full-term infants. Free T<jats:sub>4<\/jats:sub> concentrations were measured by Corning Medical radio-immunoassay (RIA) kit.<\/jats:p>\n        <jats:p>The infants with extremely low birth weight (ELBW) (body weight \u2266 1000 g) showed precipitous declines of total T<jats:sub>4<\/jats:sub> and, to a lesser extent, of FT<jats:sub>4<\/jats:sub> concentrations at 1 and 2 weeks of age. These post-natal T<jats:sub>4<\/jats:sub> and FT<jats:sub>4<\/jats:sub> decreases in ELBW neonates have not previously been reported. The clinical significance of this finding remains, speculative, but it may be due to metabolic or nutritional problems related to extreme prematurity itself.<\/jats:p>\n        <jats:p>This study suggests that measurement of FT<jats:sub>4<\/jats:sub> is a useful adjunct to the assessment of ELBW infants with wery low T<jats:sub>4<\/jats:sub> values, if done between 1 to 2 weeks af age, and could be used as a primary hypothyroid screening tool instead of T<jats:sub>4<\/jats:sub> measurements, provided that an FT<jats:sub>4<\/jats:sub> assay is developed that uses the elute of blood spotted on filter paper.<\/jats:p>","DOI":"10.1530\/acta.0.1100056","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"56-60","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":10,"title":["Post-natal thyroid function in low birth weight infants; a longitudinal assessment of free thyroxine and thyroid hormone binding globulin"],"prefix":"10.1093","volume":"110","author":[{"given":"Takeki","family":"Hirano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaideep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopal","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosita","family":"Pildes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/110\/1\/acta_110_1_011.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/110\/1\/acta_110_1_011.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:23:09Z","timestamp":1676391789000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/110\/1\/56\/6801970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1100056","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9]]}}}