{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:36Z","timestamp":1760189016333},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:p>Abstract. We measured plasma catecholamines, \u03b1- and \u03b2-adrenoreceptor numbers and the accumulation of cyclic adenosine monophosphate (cAMP) in the unstimulated state and in response to 10 \u03bcmol\/l (-) isoproterenol in blood cells from 29 euthyroid controls and from 18 patients with spontaneous hyperthyroidism. In the thyrotoxic patients plasma norepinephrine (1.14 \u00b1 0.5 nmol\/l) and epinephrine (0.3 \u00b10.14 nmol\/l) were significantly decreased compared with plasma norepinephrine (1.87 \u00b1 0.7 nmol) and epinephrine (0.41 \u00b1 0.19 nmol\/l) in the controls (<jats:italic>P<\/jats:italic> &lt; 0.01 and <jats:italic>P<\/jats:italic> &lt; 0.05, respectively) and the values obtained in subjects rendered euthyroid by antithyroid treatment (<jats:italic>P<\/jats:italic> &lt; 0.001, respectively). \u03b1-adrenoceptor density in platelet membranes obtained from patients in the hyperthyroid state (114 \u00b1 38 sites per cell) was significantly decreased when compared with controls (159 \u00b1 48 sites per cell, <jats:italic>P<\/jats:italic> &lt; 0.01) and the values from patients under effective antithyroid treatment (136 \u00b1 35 sites per cell, <jats:italic>P<\/jats:italic> &lt; 0.01). On the contrary, a significant increase in \u03b2-adrenoceptor density in mononuclear leucocyte (MNL) membranes was found in hyperthyroid patients (1751 \u00b1 237 sites\/cell) when compared with controls (1510 \u00b1 351 sites\/cell, <jats:italic>P<\/jats:italic> &lt; 0.05) and the same patients following antithyroid treatment (1455 \u00b1 260 sites\/cell, <jats:italic>P<\/jats:italic> &lt; 0.001). The equilibrium dissociation constants (K<jats:sub>D<\/jats:sub>) did not change in hyperthyroidism. Basal cAMP concentrations in MNL were higher in untreated thyrotoxicosis (45 \u00b1 18 pmol\/10<jats:sup>6<\/jats:sup> cells\/10 min) than in patients in the euthyroid state (35 \u00b1 9 pmol\/10<jats:sup>6<\/jats:sup> cells\/10 min, <jats:italic>P<\/jats:italic> &lt; 0.05). Our data support the hypothesis that the balance of \u03b1- and \u03b2-adrenoceptors depends on the thyroid state. However, before the reputed catecholamine supersensitivity in hyperthyroid man can be accepted, the relationship between alterations in adrenoceptors and the biological responsiveness to catecholamines has to be demonstrated in different human tissues.<\/jats:p>","DOI":"10.1530\/acta.0.1100075","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"75-82","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["Altered plasma catecholamines and numbers of \u03b1- and \u03b2-adrenergic receptors in platelets and leucocytes in hyperthyroid patients normalized under antithyroid treatment"],"prefix":"10.1093","volume":"110","author":[{"given":"Dieter","family":"Ratge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Hansel-Bessey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Wisser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/110\/1\/acta_110_1_015.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/110\/1\/acta_110_1_015.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:23:11Z","timestamp":1676391791000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/110\/1\/75\/6801993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1100075","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9]]}}}