{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:26:28Z","timestamp":1756992388762},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:p>Abstract. The serum free thyroxine concentration was measured by direct radioimmunoassay in 38 untreated T<jats:sub>3<\/jats:sub>-thyrotoxic patients with elevated serum total and free triiodothyronine, normal serum thyroxine and free thyroxine index, no TSH response to TRH, and with clinical evidence of hyperthyroidism. An elevation of circulating free thyroxine values was observed in 58% of the patients, whereas total serum thyroxine concentration was within the normal range. It is suggested, therefore, that T<jats:sub>3<\/jats:sub>-thyrotoxicosis should be reserved for patients with elevated serum total T<jats:sub>3<\/jats:sub> and free T<jats:sub>3<\/jats:sub> concentrations and normal serum total T<jats:sub>4<\/jats:sub> and free T<jats:sub>4<\/jats:sub> concentrations. Serum thyroxine-binding globulin concentrations were significantly lower (<jats:italic>P<\/jats:italic> &lt; 0.025) in patients with an elevated serum free thyroxine (18.7 \u00b1 3.6 \u03bcg\/ml: mean \u00b1 <jats:sc>sd<\/jats:sc>) as compared with those in patients with a normal free thyroxine concentration (23.4 \u00b1 2.6 \u03bcg\/ml). In addition, no daily fluctuations in total and free thyroxine concentration were observed in 6 patients over a 4\u20138 day period.<\/jats:p>","DOI":"10.1530\/acta.0.1100354","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"354-359","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":9,"title":["Serum free thyroxine in patients with T3-toxicosis"],"prefix":"10.1093","volume":"110","author":[{"given":"Enio","family":"Martino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pacchiarotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Aghini-Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Bambini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidio","family":"Baschieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Pinchera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/110\/3\/acta_110_3_011.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/110\/3\/acta_110_3_011.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:23:30Z","timestamp":1676391810000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/110\/3\/354\/6802025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1100354","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}