{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:23:40Z","timestamp":1760189020634},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,12]]},"abstract":"<jats:p>Abstract. Serum thyroglobulin (Tg) was measured in 52 patients 3 months to 15 years (mean 5.3 years) after thyroidectomy with or without subsequent radioablation for differentiated thyroid carcinoma, before and after the interruption of suppressive thyroxine (T<jats:sub>4<\/jats:sub>) replacement therapy for 5 weeks. Whole body scintigraphy was carried out at the end of the T<jats:sub>4<\/jats:sub> withdrawal period.<\/jats:p>\n        <jats:p>Serum Tg was undetectable (&lt; 3 \u03bcg\/l) in 38 patients on T<jats:sub>4<\/jats:sub> therapy, in 18 the scintigraphy showed a minimal accumulation in the neck region and in 20 no uptake anywhere after withdrawal of T<jats:sub>4<\/jats:sub>. In the former group Tg rose in 10 patients to 4\u201321 \u03bcg\/l when off T<jats:sub>4<\/jats:sub> which seemed to correspond to the normal tissue left in situ, in the latter group Tg rose only in 2 patients to 5 and 21 \u03bcg\/l, respectively. Two patients out of 14 with detectable Tg on T<jats:sub>4<\/jats:sub> had pulmonary metastases as uncovered by whole body scintigraphy (in one of them Tg rose from 12 \u03bcg\/l on T<jats:sub>4<\/jats:sub> to 1200 \u03bcg\/l off T<jats:sub>4<\/jats:sub>) and 6 patients were suspected for having recidual cancer tissue (2 patients had a negative scintigraphy) because the Tg rose (66\u2013 215 \u03bcg\/l) over the upper limit of the reference range (&lt; 50 \u03bcg\/l) after T<jats:sub>4<\/jats:sub> withdrawal.<\/jats:p>\n        <jats:p>In conclusion, in the follow-up of patients with differentiated thyroid carcinoma no routine scans are needed as long as serum Tg remains undetectable but further examinations are shortly warranted when detectable Tg is obtained during T<jats:sub>4<\/jats:sub> suppression.<\/jats:p>","DOI":"10.1530\/acta.0.1100487","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"487-492","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["How to deal with undetectable and low measurable serum thyroglobulin levels in the follow-up of patients with differentiated thyroid carcinoma?"],"prefix":"10.1093","volume":"110","author":[{"given":"Matti","family":"V\u00e4lim\u00e4ki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bror-Axel","family":"Lamberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/110\/4\/acta_110_4_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/110\/4\/acta_110_4_010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:23:39Z","timestamp":1676391819000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/110\/4\/487\/6802108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,12]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1100487","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,12]]}}}