{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:26:54Z","timestamp":1676438814856},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4_Suppl","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,12]]},"abstract":"<jats:title>Abstract.<\/jats:title>\n        <jats:p>Between December 1966 and June 1982, 269 transplantations of vascularized pancreas (whole or segmental) were undertaken in 254 diabetic patients throughout the world. Most of the transplantations were performed in patients with end-stage renal disease who also received kidney grafts; a few patients received pancreatic grafts only. About 25% of the pancreatic grafts are still functioning after periods of various lenghts, the longest being five years.<\/jats:p>\n        <jats:p>To the problem of how to handle the exocrine secretion there are two main approaches: 1) occlusion of the duct with a synthetic polymer and 2) pancreatico-enterostomy. A disadvantage of the former procedure is late fibrosis and atrophy of the endocrine tissue. With the latter method duct leakage and fistula development cannot be completely prevented. In either case, vascular complications cause graft failure in about 20% of the operations. The risk of rejection of the graft seems not to differ significantly from that concerning other allogeneic organs, including the kidney and heart.<\/jats:p>\n        <jats:p>Most of the patients with a functioning pancreatic graft are normoglycemic: they have a normal or near-normal oral or intravenous glucose tolerance and an early insulin response to intravenous glucose tolerance and an early insulin response to intravenous glucose challenge. Whether the improvement of the motor and sensory nerve conduction velocities observed in some patients whose graft has functioned for a long time is due to the reversal of renal insufficiency or to insulin deficiency cannot yet be determined. At present, pancreas transplantation at Huddinge Hospital is performed only in conjunction with renal transplantation in patients with end-stage diabetic renal disease.<\/jats:p>\n        <jats:p>The metabolic disturbances in animals with experimental or spontaneous diabetes mellitus can be corrected by the transplantation of either a vascularized pancreatic graft or a suspension of more or less purified islets. In insulin-dependent patients only vascularized pancreatic allografts have led to sustained normoglycemia; the results of transplanting suspensions of adult or fetal human pancreas have so far been discouraging (Sutherland, 1981b). This presentation will deal only with the transplantation of vascularized pancreatic allografts, which has proved increasingly successful in recent years. Since the first systematic clinical trial started in December, 1966, in Minnesota more than 300 pancreatic transplantations have been performed, according to the new Human Pancreas and Islet Transplant Registry (Sutherland, 1984). During the last few years the annual number of pancreas transplantations carried out in the world has greatly increased (Fig. 1), and more than 40 centers have now reported to the Registry.<\/jats:p>","DOI":"10.1530\/acta.0.110s065","type":"journal-article","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T22:32:34Z","timestamp":1256164354000},"page":"S65-S70","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic transplantation in diabetes mellitus: Present status"],"prefix":"10.1093","volume":"110","author":[{"given":"J.","family":"\u00d6stman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lundgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Tyd\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gunnarsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C-G.","family":"Groth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/110\/4_Suppl\/acta_110_Suppl_272_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/110\/4_Suppl\/acta_110_Suppl_272_010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:23:49Z","timestamp":1676391829000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/110\/4_Supplement\/S65\/6802096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,12]]},"references-count":0,"journal-issue":{"issue":"4_Suppl"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.110s065","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,12]]}}}