{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:50:39Z","timestamp":1783486239322,"version":"3.55.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,2]]},"abstract":"<jats:p>Abstract. Cardiac patients taking amiodarone, a potent anti-arrhythmic drug, often have supranormal serum thyroxine (T<jats:sub>4<\/jats:sub>) levels and normal or mildly reduced serum triiodothyronine (T<jats:sub>3<\/jats:sub>) levels. We studied T<jats:sub>4<\/jats:sub> and T<jats:sub>3<\/jats:sub> kinetics and conversion of T<jats:sub>4<\/jats:sub> to T<jats:sub>3<\/jats:sub> in 5 men with recurrent paroxysmal tachycardia before and after 5\u20136 weeks of therapy with amiodarone (dose 200\u2013800 mg\/day). The patients were also receiving various medicines for cardiac disease. Each was injected with tracer doses of labelled T<jats:sub>4<\/jats:sub> and T<jats:sub>3<\/jats:sub>; serum samples were processed by TCA precipitation and ethanol extraction. The data were analyzed with the aid of six-compartment model for T<jats:sub>4<\/jats:sub> and T<jats:sub>3<\/jats:sub> kinetics. Mean total body T<jats:sub>3<\/jats:sub> production rate, total body T<jats:sub>3<\/jats:sub> pool size, and conversion of T<jats:sub>4<\/jats:sub> to T<jats:sub>3<\/jats:sub> were all reduced in patients taking amiodarone.<\/jats:p>","DOI":"10.1530\/acta.0.1110193","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"193-199","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":26,"title":["Thyroxine and triiodothyronine kinetics in cardiac patients taking amiodarone"],"prefix":"10.1093","volume":"111","author":[{"given":"Jerome M.","family":"Hershman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koonlawee","family":"Nademanee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Eugene","family":"Pekary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bramah N.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"DiStefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/111\/2\/acta_111_2_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/111\/2\/acta_111_2_010.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:24:07Z","timestamp":1676391847000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/111\/2\/193\/6763901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1110193","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2]]}}}