{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:24:02Z","timestamp":1676438642058},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:p>Abstract. Phorbols stimulated <jats:sup>32<\/jats:sup>P incorporation into several proteins in mouse thyroid lobes. Phosphoproteins (34 K and 23 K) were detected by SDS-polyacrylamide gel electrophoresis and autoradiography. Among phorbols tested, 12-<jats:italic>O<\/jats:italic>-tetradecanoyl-phorbol-13-acetate (TPA) was the strongest stimulator of protein phosphorylation. On the other hand, TPA at 50\u2013 200 ng\/ml significantly stimulated free T<jats:sub>3<\/jats:sub> release by mouse thyroid lobes. The stimulatory effect of TPA was not additive to that of TPA or dibutyryl cAMP. TSH stimulation of free T<jats:sub>3<\/jats:sub> release by mouse thyroid lobes, however, was significantly inhibited by H-7 (an inhibitor of protein kinase C) at a concentration of 50 \u03bc<jats:sc>m<\/jats:sc>. These results suggest that protein kinase C may play some role in thyroid hormone secretion by phosphorylating the endogenous substrates.<\/jats:p>","DOI":"10.1530\/acta.0.1120217","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T21:53:47Z","timestamp":1229378027000},"page":"217-223","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["Effects of phorbol esters on protein phosphorylation and free T3 release by mouse thyroid lobes"],"prefix":"10.1093","volume":"112","author":[{"given":"Kazutaka","family":"Haraguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoshi","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimasa","family":"Onaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/112\/2\/acta_112_2_012.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/112\/2\/acta_112_2_012.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:26:34Z","timestamp":1676391994000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/112\/2\/217\/6763916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.1120217","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}